Small-molecule activation of neuronal cell fate - PubMed (original) (raw)
doi: 10.1038/nchembio.95. Epub 2008 Jun 15.
Affiliations
- PMID: 18552832
- DOI: 10.1038/nchembio.95
Small-molecule activation of neuronal cell fate
Jay W Schneider et al. Nat Chem Biol. 2008 Jul.
Abstract
We probed an epigenetic regulatory path from small molecule to neuronal gene activation. Isoxazole small molecules triggered robust neuronal differentiation in adult neural stem cells, rapidly signaling to the neuronal genome via Ca(2+) influx. Ca(2+)-activated CaMK phosphorylated and mediated nuclear export of the MEF2 regulator HDAC5, thereby de-repressing neuronal genes. These results provide new tools to explore the epigenetic signaling circuitry specifying neuronal cell fate and new leads for neuro-regenerative drugs.
Similar articles
- Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells.
Siebzehnrubl FA, Buslei R, Eyupoglu IY, Seufert S, Hahnen E, Blumcke I. Siebzehnrubl FA, et al. Exp Brain Res. 2007 Feb;176(4):672-8. doi: 10.1007/s00221-006-0831-x. Epub 2007 Jan 10. Exp Brain Res. 2007. PMID: 17216146 - Excitation-neurogenesis coupling in adult neural stem/progenitor cells.
Deisseroth K, Singla S, Toda H, Monje M, Palmer TD, Malenka RC. Deisseroth K, et al. Neuron. 2004 May 27;42(4):535-52. doi: 10.1016/s0896-6273(04)00266-1. Neuron. 2004. PMID: 15157417 - Small molecules for reprogramming and transdifferentiation.
Qin H, Zhao A, Fu X. Qin H, et al. Cell Mol Life Sci. 2017 Oct;74(19):3553-3575. doi: 10.1007/s00018-017-2586-x. Epub 2017 Jul 11. Cell Mol Life Sci. 2017. PMID: 28698932 Free PMC article. Review. - Epigenetic control of neural stem cell fate.
Hsieh J, Gage FH. Hsieh J, et al. Curr Opin Genet Dev. 2004 Oct;14(5):461-9. doi: 10.1016/j.gde.2004.07.006. Curr Opin Genet Dev. 2004. PMID: 15380235 Review.
Cited by
- Deep learning-based predictive identification of neural stem cell differentiation.
Zhu Y, Huang R, Wu Z, Song S, Cheng L, Zhu R. Zhu Y, et al. Nat Commun. 2021 May 10;12(1):2614. doi: 10.1038/s41467-021-22758-0. Nat Commun. 2021. PMID: 33972525 Free PMC article. - Coupling hippocampal neurogenesis to brain pH through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors.
Schneider JW, Goetsch SC, Leng X, Ludwig SM, Russell JL, Yang CP, Zhang QJ. Schneider JW, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):557-68. doi: 10.1021/cn300025a. Epub 2012 Mar 14. ACS Chem Neurosci. 2012. PMID: 22860225 Free PMC article. - Effects of small molecules on neurogenesis: Neuronal proliferation and differentiation.
Jastrzębski MK, Wójcik P, Stępnicki P, Kaczor AA. Jastrzębski MK, et al. Acta Pharm Sin B. 2024 Jan;14(1):20-37. doi: 10.1016/j.apsb.2023.10.007. Epub 2023 Oct 20. Acta Pharm Sin B. 2024. PMID: 38239239 Free PMC article. Review. - Hippocampal neurogenesis: Learning to remember.
Lazarov O, Hollands C. Lazarov O, et al. Prog Neurobiol. 2016 Mar-May;138-140:1-18. doi: 10.1016/j.pneurobio.2015.12.006. Epub 2016 Feb 6. Prog Neurobiol. 2016. PMID: 26855369 Free PMC article. Review. - Crosstalk among Epigenetic Pathways Regulates Neurogenesis.
Jobe EM, McQuate AL, Zhao X. Jobe EM, et al. Front Neurosci. 2012 May 8;6:59. doi: 10.3389/fnins.2012.00059. eCollection 2012. Front Neurosci. 2012. PMID: 22586361 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous