On the origins of genetic variants - PubMed (original) (raw)
Review
. 1991 Jul 22;285(2):160-4.
doi: 10.1016/0014-5793(91)80796-6.
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- PMID: 1855584
- DOI: 10.1016/0014-5793(91)80796-6
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Review
On the origins of genetic variants
U Wintersberger. FEBS Lett. 1991.
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Abstract
Two contrasting mechanisms responsible for the creation of genetic variants are described: one is the manifestation of the limited accuracy of the cellular machinery for DNA replication, the other results from the ability of cells to repair damaged DNA. Replication-dependent variants and those caused by episodical DNA damage enhance the probability that a small fraction of a cell population may survive a sudden (physical or biological) change of environmental conditions. Replication-independent variants arise during persistent but not immediately lethal stress (e.g. starvation) of a non-dividing population. The variants observed under these conditions are of selective advantage because they are able to cope with the particular stress situation. The molecular basis of their creation is a matter of intensive debate.
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