Neuroimaging in anxiety disorders - PubMed (original) (raw)

Review

. 2009 Jun;116(6):703-16.

doi: 10.1007/s00702-008-0077-9. Epub 2008 Jun 21.

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Free PMC article

Review

Neuroimaging in anxiety disorders

Kirsten Engel et al. J Neural Transm (Vienna). 2009 Jun.

Free PMC article

Abstract

Neuroimaging studies have gained increasing importance in validating neurobiological network hypotheses for anxiety disorders. Functional imaging procedures and radioligand binding studies in healthy subjects and in patients with anxiety disorders provide growing evidence of the existence of a complex anxiety network, including limbic, brainstem, temporal, and prefrontal cortical regions. Obviously, "normal anxiety" does not equal "pathological anxiety" although many phenomena are evident in healthy subjects, however to a lower extent. Differential effects of distinct brain regions and lateralization phenomena in different anxiety disorders are mentioned. An overview of neuroimaging investigations in anxiety disorders is given after a brief summary of results from healthy volunteers. Concluding implications for future research are made by the authors.

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