Tastes and structures of bitter peptide, asparagine-alanine-leucine-proline-glutamate, and its synthetic analogues - PubMed (original) (raw)
. 2008 Jul 23;56(14):5852-8.
doi: 10.1021/jf7036664. Epub 2008 Jun 25.
Affiliations
- PMID: 18576657
- DOI: 10.1021/jf7036664
Tastes and structures of bitter peptide, asparagine-alanine-leucine-proline-glutamate, and its synthetic analogues
Mi-Ryung Kim et al. J Agric Food Chem. 2008.
Erratum in
- J Agric Food Chem. 2008 Nov 12;56(21):10444
Abstract
Asn-Ala-Leu-Pro-Glu (NALPE) is a strong bitter peptide with a minimum response threshold (MRT) of 0.074 mM. To elucidate the relationship of spatial structure and bitterness on peptides, NALPE and its analogues, NALPW, NALPS, NALPL, NALPP, NALPD, and NALPR, were synthesized and sensorially evaluated. Structural analysis using computer simulation for each peptide revealed that the presence of a polar group and hydrophobic bitter amino acids, the composition of hydrophobic regions, the spatial orientation of the polar group and hydrophobic regions, and the proximity between polar groups and hydrophobic regions faced within the same plane space may be the major determinants for the taste type and intensity of peptide bitterness.
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