Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins - PubMed (original) (raw)

. 1991 Jul 19;253(5017):312-4.

doi: 10.1126/science.1857966.

Affiliations

• PMID: 1857966
• DOI: 10.1126/science.1857966

Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins

S Piñol-Roma et al. Science. 1991.

Abstract

Heterogeneous nuclear RNAs and specific nuclear proteins form heterogeneous nuclear ribonucleoprotein complexes (hnRNPs), one of the most abundant components of the nucleus. In mitosis, as the nuclear envelope breaks down, hnRNPs disperse throughout the cell. At the end of mitosis, hnRNPs dissociate and their proteins are transported into the daughter cell nuclei separately. Some are transported immediately (early group), while others are transported later (late group). Transport of the late group appears to require transcription by RNA polymerase II, in that inhibitors of this polymerase cause the late proteins to remain in the cytoplasm. Thus, there are two modes, transcription-dependent and transcription-independent, for the transport of nuclear proteins.

PubMed Disclaimer

Similar articles

• Cell cycle-regulated phosphorylation of the pre-mRNA-binding (heterogeneous nuclear ribonucleoprotein) C proteins.
  Piñol-Roma S, Dreyfuss G. Piñol-Roma S, et al. Mol Cell Biol. 1993 Sep;13(9):5762-70. doi: 10.1128/mcb.13.9.5762-5770.1993. Mol Cell Biol. 1993. PMID: 8395012 Free PMC article.
• Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.
  Piñol-Roma S, Dreyfuss G. Piñol-Roma S, et al. Nature. 1992 Feb 20;355(6362):730-2. doi: 10.1038/355730a0. Nature. 1992. PMID: 1371331
• Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm.
  Kim JH, Hahm B, Kim YK, Choi M, Jang SK. Kim JH, et al. J Mol Biol. 2000 May 5;298(3):395-405. doi: 10.1006/jmbi.2000.3687. J Mol Biol. 2000. PMID: 10772858
• Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles.
  Chaudhury A, Chander P, Howe PH. Chaudhury A, et al. RNA. 2010 Aug;16(8):1449-62. doi: 10.1261/rna.2254110. Epub 2010 Jun 28. RNA. 2010. PMID: 20584894 Free PMC article. Review.
• The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolism.
  Weighardt F, Biamonti G, Riva S. Weighardt F, et al. Bioessays. 1996 Sep;18(9):747-56. doi: 10.1002/bies.950180910. Bioessays. 1996. PMID: 8831291 Review.

Cited by

• A Quantitative Heterokaryon Assay to Measure the Nucleocytoplasmic Shuttling of Proteins.
  McNicoll F, Müller-McNicoll M. McNicoll F, et al. Bio Protoc. 2018 Sep 5;8(17):e2472. doi: 10.21769/BioProtoc.2472. eCollection 2018 Sep 5. Bio Protoc. 2018. PMID: 34395784 Free PMC article.
• A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis.
  An S, Kwon OS, Yu J, Jang SK. An S, et al. Cell Mol Life Sci. 2020 Nov;77(22):4693-4708. doi: 10.1007/s00018-019-03436-3. Epub 2020 Feb 6. Cell Mol Life Sci. 2020. PMID: 32030451 Free PMC article.
• hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation.
  Batlle C, Yang P, Coughlin M, Messing J, Pesarrodona M, Szulc E, Salvatella X, Kim HJ, Taylor JP, Ventura S. Batlle C, et al. Cell Rep. 2020 Jan 28;30(4):1117-1128.e5. doi: 10.1016/j.celrep.2019.12.080. Cell Rep. 2020. PMID: 31995753 Free PMC article.
• Heterogeneous Nuclear Ribonucleoprotein A1 and Lamin A/C Modulate Nucleocytoplasmic Shuttling of Avian Reovirus p17.
  Chiu HC, Huang WR, Wang YY, Li JY, Liao TL, Nielsen BL, Liu HJ. Chiu HC, et al. J Virol. 2019 Sep 30;93(20):e00851-19. doi: 10.1128/JVI.00851-19. Print 2019 Oct 15. J Virol. 2019. PMID: 31375578 Free PMC article.
• Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression.
  Hsu MC, Pan MR, Chu PY, Tsai YL, Tsai CH, Shan YS, Chen LT, Hung WC. Hsu MC, et al. Cancers (Basel). 2018 Dec 20;11(1):8. doi: 10.3390/cancers11010008. Cancers (Basel). 2018. PMID: 30577570 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon