Replication of association between ELAVL4 and Parkinson disease: the GenePD study - PubMed (original) (raw)

Multicenter Study

doi: 10.1007/s00439-008-0526-4. Epub 2008 Jun 29.

Jeanne Latourelle, Mark F Lew, Oksana Suchowersky, Christine Klein, Lawrence I Golbe, Margery H Mark, John H Growdon, G Fredrick Wooten, Ray Watts, Mark Guttman, Brad A Racette, Joel S Perlmutter, Lynn Marlor, Holly A Shill, Carlos Singer, Stefano Goldwurm, Gianni Pezzoli, Marie H Saint-Hilaire, Audrey E Hendricks, Adam Gower, Sally Williamson, Michael W Nagle, Jemma B Wilk, Tiffany Massood, Karen W Huskey, Kenneth B Baker, Ilia Itin, Irene Litvan, Garth Nicholson, Alastair Corbett, Martha Nance, Edward Drasby, Stuart Isaacson, David J Burn, Patrick F Chinnery, Peter P Pramstaller, Jomana Al-Hinti, Anette T Moller, Karen Ostergaard, Scott J Sherman, Richard Roxburgh, Barry Snow, John T Slevin, Franca Cambi, James F Gusella, Richard H Myers

Affiliations

Multicenter Study

Replication of association between ELAVL4 and Parkinson disease: the GenePD study

Anita L DeStefano et al. Hum Genet. 2008 Aug.

Abstract

Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the GenePD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the GenePD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.

PubMed Disclaimer

Figures

Fig. 1

Fig. 1

Odds ratio and 95% confidence interval for risk of PD affection status with increasing number of minor alleles of rs967582 from the current analysis (GenePD) and previously published populations (Haugarvoll et al. 2007). Another study in a US population found no association using a pedigree disequilbrium test. This study is not included in the figure as no effect measure was available (Noureddine et al. 2005)

References

    1. Aranda-Abreu GE, Behar L, Chung S, Furneaux H, Ginzburg I. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. J Neurosci. 1999;19:6907–6917. - PMC - PubMed
    1. Bonifati V, Rizzu P, Squitieri F, Krieger E, Vanacore N, van Swieten JC, Brice A, van Duijn CM, Oostra B, Meco G, Heutink P. DJ-1(PARK7), a novel gene for autosomal recessive, early onset parkinsonism. Neurol Sci. 2003;24:159–160. - PubMed
    1. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1988;51:745–752. - PMC - PubMed
    1. Haugarvoll K, Toft M, Ross OA, Stone JT, Heckman MG, White LR, Lynch T, Gibson JM, Wszolek ZK, Uitti RJ, Aasly JO, Farrer MJ. ELAVL4, PARK10, and the Celts. Mov Disord. 2007;22:585–587. - PubMed
    1. Healy DG, Abou-Sleiman PM, Lees AJ, Casas JP, Quinn N, Bhatia K, Hingorani AD, Wood NW. Tau gene and Parkinson’s disease: a case-control study and meta-analysis. J Neurol Neurosurg Psychiatry. 2004;75:962–965. - PMC - PubMed

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources