TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells - PubMed (original) (raw)
doi: 10.1080/07357900801941852.
Junfang Deng, Lei Geng, Haiyang Xie, Guoping Jiang, Lin Zhou, Yan Wang, Shenyong Yin, Xiaowen Feng, Junwei Liu, Zhou Ye, Shusen Zheng
Affiliations
- PMID: 18608206
- DOI: 10.1080/07357900801941852
TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells
Yigang Qian et al. Cancer Invest. 2008 Oct.
Abstract
TLR4 (Toll-like receptor 4) and B7-H1, which were known to be restricted to immune cells in the past, were found to be aberrantly expressed in a majority of tumor cells, facilitating tumor evasion from immune surveillance. Our study demonstrated that activation of TLR4 signaling in bladder cancer cells up-regulated B7-H1 expression. Furthermore, this regulation was significantly attenuated by ERK or JNK inhibitor. Our results elucidated the molecule mechanism of regulation of B7-H1 expression through TLR4 signaling and may suggest new strategies of down-regulating the cancer-associated B7-H1 expression for bladder cancer treatment.
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