Molecular polymorphism of Abeta in Alzheimer's disease - PubMed (original) (raw)

Molecular polymorphism of Abeta in Alzheimer's disease

Harry Levine 3rd et al. Neurobiol Aging. 2010 Apr.

Abstract

Alzheimer's disease is defined pathologically by the presence of senile plaques, which consist primarily of extracellular aggregates of fibrillar Abeta peptide, and neurofibrillary tangles, which are abnormal, intracellular bundles of fibrillar tau protein. The advent of amyloid binding agents as diagnostic imaging probes for Alzheimer's disease (AD) has made it imperative to understand at a molecular and disease level what these ligands are reporting. In addition to improving the accuracy of diagnosis, we argue that these selective ligands can serve as probes for molecular polymorphisms that may govern the pathogenicity of abnormal protein aggregates.

Copyright (c) 2008 Elsevier Inc. All rights reserved.

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Conflict of interest statement

The authors declare that there are no actual or potential conflicts of interest for the views expressed in this manuscript

Figures

Figure 1

Figure 1

Amyloid-Binding Ligands

  1. [1]
    Thioflavine T
  2. [2]
    PIB1
  3. [3]
    BTA-1
  4. [4]
    IMPY
  5. [5]
    Thioflavine S (mixture)
  6. [6]
    Congo Red
  7. [7]
    Chrysamine G
  8. [8]
    X-34
  9. [9]
    BSB

Figure 1

Figure 1

Amyloid-Binding Ligands

  1. [1]
    Thioflavine T
  2. [2]
    PIB1
  3. [3]
    BTA-1
  4. [4]
    IMPY
  5. [5]
    Thioflavine S (mixture)
  6. [6]
    Congo Red
  7. [7]
    Chrysamine G
  8. [8]
    X-34
  9. [9]
    BSB

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References

    1. Aguzzi A, Heikenwalder M, Polymenidou M. Insights into prion strains and neurotoxicity. Nat Rev Mol Cell Biol. 2007;8(7):552–61. - PubMed
    1. Aslund A, Herland A, Hammarstrom P, Nilsson KP, Jonsson BH, Inganas O, Konradsson P. Studies of Luminescent Conjugated Polythiophene Derivatives: Enhanced Spectral Discrimination of Protein Conformational States. Bioconjug Chem. 2007 - PubMed
    1. Attems J, Lintner F, Jellinger KA. Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology. Acta Neuropathol (Berl) 2004;107(4):283–91. - PubMed
    1. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006;66(12):1837–44. - PubMed
    1. Bierer LM, Hof PR, Purohit DP, Carlin L, Schmeidler J, Davis KL, Perl DP. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer’s disease. Arch Neurol. 1995;52(1):81–8. - PubMed

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