Widespread changes in dendritic spines in a model of Alzheimer's disease - PubMed (original) (raw)

Comparative Study

doi: 10.1093/cercor/bhn111. Epub 2008 Jul 16.

Affiliations

• PMID: 18632740
• DOI: 10.1093/cercor/bhn111

Comparative Study

Widespread changes in dendritic spines in a model of Alzheimer's disease

S Knafo et al. Cereb Cortex. 2009 Mar.

Abstract

The mechanism by which dementia occurs in patients with Alzheimer's disease (AD) is not known. We assessed changes in hippocampal dendritic spines of APP/PS1 transgenic mice that accumulate amyloid beta throughout the brain. Three-dimensional analysis of 21,507 dendritic spines in the dentate gyrus, a region crucial for learning and memory, revealed a substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice. Plaque-related dendrites also show striking alterations in spine density and morphology. However, plaques occupy only 3.9% of the molecular layer volume. Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contributes to the cognitive impairments observed in this AD model.

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