The life, death, and replacement of oligodendrocytes in the adult CNS - PubMed (original) (raw)
Review
The life, death, and replacement of oligodendrocytes in the adult CNS
Dana M McTigue et al. J Neurochem. 2008 Oct.
Free article
Abstract
Oligodendrocytes (OLs) are mature glial cells that myelinate axons in the brain and spinal cord. As such, they are integral to functional and efficient neuronal signaling. The embryonic lineage and postnatal development of OLs have been well-studied and many features of the process have been described, including the origin, migration, proliferation, and differentiation of precursor cells. Less clear is the extent to which OLs and damaged/dysfunctional myelin are replaced following injury to the adult CNS. OLs and their precursors are very vulnerable to conditions common to CNS injury and disease sites, such as inflammation, oxidative stress, and elevated glutamate levels leading to excitotoxicity. Thus, these cells become dysfunctional or die in multiple pathologies, including Alzheimer's disease, spinal cord injury, Parkinson's disease, ischemia, and hypoxia. However, studies of certain conditions to date have detected spontaneous OL replacement. This review will summarize current information on adult OL progenitors, mechanisms that contribute to OL death, the consequences of their loss and the pathological conditions in which spontaneous oligodendrogenesis from endogenous precursors has been observed in the adult CNS.
Similar articles
- Olig2-expressing progenitor cells preferentially differentiate into oligodendrocytes in cuprizone-induced demyelinated lesions.
Islam MS, Tatsumi K, Okuda H, Shiosaka S, Wanaka A. Islam MS, et al. Neurochem Int. 2009 Mar-Apr;54(3-4):192-8. doi: 10.1016/j.neuint.2008.10.011. Epub 2008 Nov 27. Neurochem Int. 2009. PMID: 19070638 - Spatial and temporal expression of S100B in cells of oligodendrocyte lineage.
Hachem S, Aguirre A, Vives V, Marks A, Gallo V, Legraverend C. Hachem S, et al. Glia. 2005 Aug 1;51(2):81-97. doi: 10.1002/glia.20184. Glia. 2005. PMID: 15782413 - Olig gene function in CNS development and disease.
Ligon KL, Fancy SP, Franklin RJ, Rowitch DH. Ligon KL, et al. Glia. 2006 Jul;54(1):1-10. doi: 10.1002/glia.20273. Glia. 2006. PMID: 16652341 Review. - Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells.
Calzà L, Fernandez M, Giardino L. Calzà L, et al. J Mol Endocrinol. 2010 Jan;44(1):13-23. doi: 10.1677/JME-09-0067. Epub 2009 Jul 3. J Mol Endocrinol. 2010. PMID: 19578096 Review. - Polydendrocytes: NG2 cells with many roles in development and repair of the CNS.
Nishiyama A. Nishiyama A. Neuroscientist. 2007 Feb;13(1):62-76. doi: 10.1177/1073858406295586. Neuroscientist. 2007. PMID: 17229976 Review.
Cited by
- Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease.
Zota I, Chanoumidou K, Gravanis A, Charalampopoulos I. Zota I, et al. Front Cell Neurosci. 2024 Sep 2;18:1422130. doi: 10.3389/fncel.2024.1422130. eCollection 2024. Front Cell Neurosci. 2024. PMID: 39285941 Free PMC article. Review. - Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism.
Louie AY, Drnevich J, Johnson JL, Woodard M, Kukekova AV, Johnson RW, Steelman AJ. Louie AY, et al. iScience. 2024 Jul 5;27(8):110464. doi: 10.1016/j.isci.2024.110464. eCollection 2024 Aug 16. iScience. 2024. PMID: 39104416 Free PMC article. - Unraveling the complexity of human brain: Structure, function in healthy and disease states.
Sultana OF, Bandaru M, Islam MA, Reddy PH. Sultana OF, et al. Ageing Res Rev. 2024 Sep;100:102414. doi: 10.1016/j.arr.2024.102414. Epub 2024 Jul 15. Ageing Res Rev. 2024. PMID: 39002647 Review. - Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey.
Gonzalez Ramirez C, Salvador SG, Patel RKR, Clark S, Miller NW, James LM, Ringelberg NW, Simon JM, Bennett J, Amaral DG, Burette AC, Philpot BD. Gonzalez Ramirez C, et al. Front Neuroanat. 2024 May 30;18:1410791. doi: 10.3389/fnana.2024.1410791. eCollection 2024. Front Neuroanat. 2024. PMID: 38873093 Free PMC article. - Antidepressant effect of teriflunomide via oligodendrocyte protection in a mouse model.
Luo S, Wu F, Fang Q, Hu Y, Zhang H, Yuan S, Yang C, Shi Y, Luo Y. Luo S, et al. Heliyon. 2024 Apr 10;10(8):e29481. doi: 10.1016/j.heliyon.2024.e29481. eCollection 2024 Apr 30. Heliyon. 2024. PMID: 38655332 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials