Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs - PubMed (original) (raw)
. 2008 Aug 12;14(2):111-22.
doi: 10.1016/j.ccr.2008.07.002. Epub 2008 Jul 24.
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- PMID: 18656424
- DOI: 10.1016/j.ccr.2008.07.002
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Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
Karen E Gascoigne et al. Cancer Cell. 2008.
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Abstract
Drugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingly, little is known about how they kill tumor cells. This is largely because many of the population-based approaches are indirect and lead to vague and confusing interpretations. Here, we use a high-throughput automated time-lapse light microscopy approach to systematically analyze over 10,000 single cells from 15 cell lines in response to three different classes of antimitotic drug. We show that the variation in cell behavior is far greater than previously recognized, with cells within any given line exhibiting multiple fates. We present data supporting a model wherein cell fate is dictated by two competing networks, one involving caspase activation, the other protecting cyclin B1 from degradation.
Comment in
- Beyond genetics: surprising determinants of cell fate in antitumor drugs.
Holland AJ, Cleveland DW. Holland AJ, et al. Cancer Cell. 2008 Aug 12;14(2):103-5. doi: 10.1016/j.ccr.2008.07.010. Cancer Cell. 2008. PMID: 18691543 Free PMC article.
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