Mechanisms of YidC-mediated insertion and assembly of multimeric membrane protein complexes - PubMed (original) (raw)
Review
. 2008 Nov 14;283(46):31269-73.
doi: 10.1074/jbc.R800029200. Epub 2008 Jul 25.
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- PMID: 18658156
- DOI: 10.1074/jbc.R800029200
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Review
Mechanisms of YidC-mediated insertion and assembly of multimeric membrane protein complexes
Stefan Kol et al. J Biol Chem. 2008.
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Abstract
The YidC protein fulfills a dual and essential role in the assembly of inner membrane proteins in Escherichia coli. Besides interacting with transmembrane segments of newly synthesized membrane proteins that insert into the membrane via the SecYEG complex, YidC also functions as an independent membrane protein insertase and assists in membrane protein folding. Here, we discuss the mechanisms of YidC substrate recognition and membrane insertion with emphasis on its role in the assembly of multimeric membrane protein complexes such as the F1F0-ATP synthase.
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