Common west African HLA antigens are associated with protection from severe malaria - PubMed (original) (raw)

. 1991 Aug 15;352(6336):595-600.

doi: 10.1038/352595a0.

Affiliations

• PMID: 1865923
• DOI: 10.1038/352595a0

Common west African HLA antigens are associated with protection from severe malaria

A V Hill et al. Nature. 1991.

Abstract

A large case-control study of malaria in West African children shows that a human leucocyte class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1*1302-DQB1*0501), common in West Africans but rare in other racial groups, are independently associated with protection from severe malaria. In this population they account for as great a reduction in disease incidence as the sickle-cell haemoglobin variant. These data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.

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Comment in

• Maintenance of MHC polymorphism.
  Hughes AL, Nei M. Hughes AL, et al. Nature. 1992 Jan 30;355(6359):402-3. doi: 10.1038/355402b0. Nature. 1992. PMID: 1734277 No abstract available.
• Immunology. Disease and evolution.
  Howard JC. Howard JC. Nature. 1991 Aug 15;352(6336):565-7. doi: 10.1038/352565a0. Nature. 1991. PMID: 1865919 No abstract available.

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