Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice - PubMed (original) (raw)
. 2008 Dec;23(12):2048-59.
doi: 10.1359/jbmr.080808.
Affiliations
- PMID: 18684086
- DOI: 10.1359/jbmr.080808
Free article
Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice
Helen R Buie et al. J Bone Miner Res. 2008 Dec.
Free article
Abstract
An understanding of normal microarchitectural bone development patterns of common murine models is needed. Longitudinal, structural, and mineralization trends were evaluated by in vivo microCT over 12 time points from 6-48 wk of age at the vertebra and tibia of C3H/HeN, C57BL/6, and BALB/C mice. Longitudinal growth occurred rapidly until 8-10 wk, slowed as the growth plate bridged, and fused at 8-10 mo. Structural augmentation occurred through formation of trabeculae at the growth plate and thickening of existing ones. In the vertebrae, BV/TV increased rapidly until 12 wk in all strains. Between 12 and 32 wk, the architecture was stable with BV/TV deviating <1.1%, 1.6%, and 3.4% for the C57BL/6, BALB/C, and C3H/HeN mice. In contrast, the tibial architecture changed continuously but more moderately for BV/TV and TbTh compared with the vertebra and with comparable or larger changes for TbN and TbSp. Age-related trabecular deterioration (decreased BV/TV and TbN; increased TbSp and structure model index) was evident at both sites at 32 wk. In all strains, the cortex continued to develop after trabecular values peaked. The temporal plateau of BMD was variable across mouse strains and site, whereas tissue mineral density was attained at approximately 6 mo for all sites and strains. Geometric changes at the tibial diaphysis occurred rapidly until 8-10 wk, providing the C57BL/6 mice and C3H/HeN mice with the highest torsional and compressive rigidity, respectively. In summary, key skeletal development milestones were identified, and architectural topology at the vertebra was found to be more stable than at the tibia.
Similar articles
- Age-related changes in trabecular architecture differ in female and male C57BL/6J mice.
Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Glatt V, et al. J Bone Miner Res. 2007 Aug;22(8):1197-207. doi: 10.1359/jbmr.070507. J Bone Miner Res. 2007. PMID: 17488199 - Evaluation of changes in trabecular bone architecture and mechanical properties of minipig vertebrae by three-dimensional magnetic resonance microimaging and finite element modeling.
Borah B, Dufresne TE, Cockman MD, Gross GJ, Sod EW, Myers WR, Combs KS, Higgins RE, Pierce SA, Stevens ML. Borah B, et al. J Bone Miner Res. 2000 Sep;15(9):1786-97. doi: 10.1359/jbmr.2000.15.9.1786. J Bone Miner Res. 2000. PMID: 10976998 - Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice.
Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Müller R, Beamer WG. Bouxsein ML, et al. J Bone Miner Res. 2004 Apr;19(4):587-99. doi: 10.1359/JBMR.0301255. Epub 2003 Dec 22. J Bone Miner Res. 2004. PMID: 15005846 - Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography.
David V, Laroche N, Boudignon B, Lafage-Proust MH, Alexandre C, Ruegsegger P, Vico L. David V, et al. J Bone Miner Res. 2003 Sep;18(9):1622-31. doi: 10.1359/jbmr.2003.18.9.1622. J Bone Miner Res. 2003. PMID: 12968671 - Strain-dependent variations in the response of cancellous bone to ovariectomy in mice.
Iwaniec UT, Yuan D, Power RA, Wronski TJ. Iwaniec UT, et al. J Bone Miner Res. 2006 Jul;21(7):1068-74. doi: 10.1359/jbmr.060402. J Bone Miner Res. 2006. PMID: 16813527
Cited by
- Bisphosphonate conjugation enhances the bone-specificity of NELL-1-based systemic therapy for spaceflight-induced bone loss in mice.
Ha P, Kwak JH, Zhang Y, Shi J, Tran L, Liu TP, Pan HC, Lee S, Kim JK, Chen E, Shirazi-Fard Y, Stodieck LS, Lin A, Zheng Z, Dong SN, Zhang X, Wu BM, Ting K, Soo C. Ha P, et al. NPJ Microgravity. 2023 Sep 18;9(1):75. doi: 10.1038/s41526-023-00319-7. NPJ Microgravity. 2023. PMID: 37723136 Free PMC article. - Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging.
Catheline SE, Kaiser E, Eliseev RA. Catheline SE, et al. Curr Osteoporos Rep. 2023 Oct;21(5):540-551. doi: 10.1007/s11914-023-00816-4. Epub 2023 Aug 5. Curr Osteoporos Rep. 2023. PMID: 37542684 Review. - Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight.
Bedree JK, Kerns K, Chen T, Lima BP, Liu G, Ha P, Shi J, Pan HC, Kim JK, Tran L, Minot SS, Hendrickson EL, Lamont EI, Schulte F, Hardt M, Stephens D, Patel M, Kokaras A, Stodieck L, Shirazi-Fard Y, Wu B, Kwak JH, Ting K, Soo C, McLean JS, He X, Shi W. Bedree JK, et al. Cell Rep. 2023 May 30;42(5):112299. doi: 10.1016/j.celrep.2023.112299. Epub 2023 Apr 19. Cell Rep. 2023. PMID: 37080202 Free PMC article. - Lead induced differences in bone properties in osteocalcin +/+ and -/- female mice.
Yildirim G, Budell WC, Berezovska O, Yagerman S, Maliath SS, Mastrokostas P, Tommasini S, Dowd TL. Yildirim G, et al. Bone Rep. 2023 Mar 17;18:101672. doi: 10.1016/j.bonr.2023.101672. eCollection 2023 Jun. Bone Rep. 2023. PMID: 37064000 Free PMC article. - Intestinal Vitamin D Receptor Is Dispensable for Maintaining Adult Bone Mass in Mice With Adequate Calcium Intake.
Jiang H, Chanpaisaeng K, Christakos S, Fleet JC. Jiang H, et al. Endocrinology. 2023 Mar 13;164(5):bqad051. doi: 10.1210/endocr/bqad051. Endocrinology. 2023. PMID: 36960562 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources