Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia - PubMed (original) (raw)

Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia

Costas G Hadjipanayis et al. Small. 2008 Nov.

No abstract available

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Figures

Figure 1

Transmission electron microscopy data: a) schematic image of the polymer-coated Fe-based metallic nanoparticles, b) high-resolution image, c) bright-field image showing coated FeNPs. d) SAED image confirming the body-centered cubic (bcc) structure of α Fe together with a small amount of FeO.

Figure 2

Hysteresis loops for FeNP and IONP taken at room temperature.

Figure 3

Hyperthermia data for FeNPs and IONPs using 500 MHz and 4 Oe AC magnetic field.

Figure 4

Decreasing signal density at different echo times showed typical paramagnetic-induced _T_2 decay in different samples (A). A set of _T_2-weighted fast spin–echo images showed the strong _T_2 contrast from FeNPs and IONPs (darkening effect) in contrast to the H2O phantom (B, upper panel) while a _T_2 relaxometry map derived from the multi-TE T2 measurement showed a substantially lower _T_2 value of the FeNPs (B, lower panel). _T_2 images were recorded using a multi-TE fast spin–echo imaging sequence with a TR of 3 s and 32 TE points (starting at 6 ms with increments of 6 ms). The sample concentrations of IONPs and FeNPs shown in the Figure are 0.11 and 0.12 m

m

, respectively.

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