PPAR-gamma and aging: one link through klotho? - PubMed (original) (raw)
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doi: 10.1038/ki.2008.382.
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- PMID: 18756295
- DOI: 10.1038/ki.2008.382
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PPAR-gamma and aging: one link through klotho?
Ruihua Zhang et al. Kidney Int. 2008 Sep.
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Abstract
PPAR-gamma, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-gamma may prompt further exploration of the role and mechanism of action of PPAR-gamma in aging and bone diseases.
Comment on
- Klotho is a target gene of PPAR-gamma.
Zhang H, Li Y, Fan Y, Wu J, Zhao B, Guan Y, Chien S, Wang N. Zhang H, et al. Kidney Int. 2008 Sep;74(6):732-9. doi: 10.1038/ki.2008.244. Epub 2008 Jun 11. Kidney Int. 2008. PMID: 18547997
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