Base excision repair and its role in maintaining genome stability - PubMed (original) (raw)
Review
. 2008 Jul-Aug;43(4):239-76.
doi: 10.1080/10409230802309905.
Affiliations
- PMID: 18756381
- DOI: 10.1080/10409230802309905
Review
Base excision repair and its role in maintaining genome stability
Joke Baute et al. Crit Rev Biochem Mol Biol. 2008 Jul-Aug.
Abstract
For all living organisms, genome stability is important, but is also under constant threat because various environmental and endogenous damaging agents can modify the structural properties of DNA bases. As a defense, organisms have developed different DNA repair pathways. Base excision repair (BER) is the predominant pathway for coping with a broad range of small lesions resulting from oxidation, alkylation, and deamination, which modify individual bases without large effect on the double helix structure. As, in mammalian cells, this damage is estimated to account daily for 10(4) events per cell, the need for BER pathways is unquestionable. The damage-specific removal is carried out by a considerable group of enzymes, designated as DNA glycosylases. Each DNA glycosylase has its unique specificity and many of them are ubiquitous in microorganisms, mammals, and plants. Here, we review the importance of the BER pathway and we focus on the different roles of DNA glycosylases in various organisms.
Similar articles
- Repair and genetic consequences of endogenous DNA base damage in mammalian cells.
Barnes DE, Lindahl T. Barnes DE, et al. Annu Rev Genet. 2004;38:445-76. doi: 10.1146/annurev.genet.38.072902.092448. Annu Rev Genet. 2004. PMID: 15568983 Review. - Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells.
Hegde ML, Hazra TK, Mitra S. Hegde ML, et al. Cell Res. 2008 Jan;18(1):27-47. doi: 10.1038/cr.2008.8. Cell Res. 2008. PMID: 18166975 Free PMC article. Review. - DNA repair in mammalian cells: Base excision repair: the long and short of it.
Robertson AB, Klungland A, Rognes T, Leiros I. Robertson AB, et al. Cell Mol Life Sci. 2009 Mar;66(6):981-93. doi: 10.1007/s00018-009-8736-z. Cell Mol Life Sci. 2009. PMID: 19153658 Free PMC article. Review. - BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis.
Kaina B, Ochs K, Grösch S, Fritz G, Lips J, Tomicic M, Dunkern T, Christmann M. Kaina B, et al. Prog Nucleic Acid Res Mol Biol. 2001;68:41-54. doi: 10.1016/s0079-6603(01)68088-7. Prog Nucleic Acid Res Mol Biol. 2001. PMID: 11554312 Review. - Oxidative DNA damage repair in mammalian cells: a new perspective.
Hazra TK, Das A, Das S, Choudhury S, Kow YW, Roy R. Hazra TK, et al. DNA Repair (Amst). 2007 Apr 1;6(4):470-80. doi: 10.1016/j.dnarep.2006.10.011. Epub 2006 Nov 20. DNA Repair (Amst). 2007. PMID: 17116430 Free PMC article. Review.
Cited by
- Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles.
Ren M, Gut F, Fan Y, Ma J, Shan X, Yikilmazsoy A, Likhodeeva M, Hopfner KP, Zhou C. Ren M, et al. Nat Commun. 2024 Oct 31;15(1):9407. doi: 10.1038/s41467-024-53811-3. Nat Commun. 2024. PMID: 39477986 Free PMC article. - How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation.
Azzouz D, Palaniyar N. Azzouz D, et al. Biomolecules. 2024 Oct 16;14(10):1307. doi: 10.3390/biom14101307. Biomolecules. 2024. PMID: 39456240 Free PMC article. Review. - Intragenomic rDNA variation - the product of concerted evolution, mutation, or something in between?
Wang W, Zhang X, Garcia S, Leitch AR, Kovařík A. Wang W, et al. Heredity (Edinb). 2023 Sep;131(3):179-188. doi: 10.1038/s41437-023-00634-5. Epub 2023 Jul 4. Heredity (Edinb). 2023. PMID: 37402824 Free PMC article. Review. - Bacillus subtilis encodes a discrete flap endonuclease that cleaves RNA-DNA hybrids.
Lowder FC, Simmons LA. Lowder FC, et al. PLoS Genet. 2023 May 5;19(5):e1010585. doi: 10.1371/journal.pgen.1010585. eCollection 2023 May. PLoS Genet. 2023. PMID: 37146086 Free PMC article. - Archaeal DNA alkylation repair conducted by DNA glycosylase and methyltransferase.
Yin Y, Zhang L. Yin Y, et al. Appl Microbiol Biotechnol. 2023 May;107(10):3131-3142. doi: 10.1007/s00253-023-12506-3. Epub 2023 Apr 10. Appl Microbiol Biotechnol. 2023. PMID: 37036526 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials