A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells - PubMed (original) (raw)
. 2008 Sep 5;321(5894):1357-61.
doi: 10.1126/science.1156725.
Affiliations
- PMID: 18772439
- DOI: 10.1126/science.1156725
A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells
Hui Li et al. Science. 2008.
Erratum in
- Erratum for the Report "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells" by H. Li, J. Wang, G. Mor, J. Sklar.
[No authors listed] [No authors listed] Science. 2015 Oct 2;350(6256):aad3463. doi: 10.1126/science.aad3463. Science. 2015. PMID: 26430125 No abstract available. - Errata.
[No authors listed] [No authors listed] Science. 2015 Nov 20;350(6263):921. doi: 10.1126/science.350.6263.921. Science. 2015. PMID: 26586756
Abstract
Chromosomal rearrangements that create gene fusions are common features of human tumors. The prevailing view is that the resultant chimeric transcripts and proteins are abnormal, tumor-specific products that provide tumor cells with a growth and/or survival advantage. We show that normal endometrial stromal cells contain a specific chimeric RNA joining 5' exons of the JAZF1 gene on chromosome 7p15 to 3' exons of the Polycomb group gene JJAZ1/SUZ12 on chromosome 17q11 and that this RNA is translated into JAZF1-JJAZ1, a protein with anti-apoptotic activity. The JAZF1-JJAZ1 RNA appears to arise from physiologically regulated trans-splicing between precursor messenger RNAs for JAZF1 and JJAZ1. The chimeric RNA and protein are identical to those produced from a gene fusion found in human endometrial stromal tumors. These observations suggest that certain gene fusions may be pro-neoplastic owing to constitutive expression of chimeric gene products normally generated by trans-splicing of RNAs in developing tissues.
Comment in
- Medicine. The cart before the horse.
Rowley JD, Blumenthal T. Rowley JD, et al. Science. 2008 Sep 5;321(5894):1302-4. doi: 10.1126/science.1163791. Science. 2008. PMID: 18772424 No abstract available.
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