Common variants of FUT2 are associated with plasma vitamin B12 levels - PubMed (original) (raw)
. 2008 Oct;40(10):1160-2.
doi: 10.1038/ng.210. Epub 2008 Sep 7.
Affiliations
- PMID: 18776911
- PMCID: PMC2673801
- DOI: 10.1038/ng.210
Common variants of FUT2 are associated with plasma vitamin B12 levels
Aditi Hazra et al. Nat Genet. 2008 Oct.
Abstract
We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.
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References
- Siva A, et al. Qjm. 2007;100:495–499. - PubMed
- Watanabe F. Exp Biol Med (Maywood) 2007;232:1266–1274. - PubMed
- Kang JH, et al. Epidemiology. 2006;17:650–657. - PubMed
- Dahlin AM, et al. Int J Cancer. 2008;122:2057–2061. - PubMed
- Tanner SM, et al. Hum Mutat. 2004;23:327–333. - PubMed
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