Function and dysfunction of the PI system in membrane trafficking - PubMed (original) (raw)

Figure 4

Interaction map of the products of the genes responsible or candidate for disorders of kidney proximal tubule cells (PTCs). The genes responsible or strong candidate for diseases due to dysfunction of kidney PTCs are shown (large red ellipses), together with selected interactors, including genes for which the knock out causes proteinuria and tubular acidosis in mice (rectangles). The interaction map was generated using Osprey (powered by Human GRID, General Repository of Interaction Datasets). The components of the network that are active on or sensitive to PI45P2 (the substrate of the 5-phosphatase OCRL) are marked in yellow. LRP2 encodes for megalin, a multiligand receptor that, together with cubilin (CBN), is responsible for the resorption of the indicated LMW proteins by PTCs (Igarashi et al, 2002; Christensen and Gburek, 2004). ARH, autosomal recessive hypercholesterolaemia; DAB2, disabled homologue 2; GIPC, GAIP C terminus interacting protein; PIP5K1C, phosphatidylinositol-4-phosphate 5-kinase type I gamma; SYNJ2BP, synaptojanin 2-binding protein; CLTC, clathrin heavy chain 1; AP2M1, clathrin coat assembly protein AP50, Myo VI, myosin 6, APPL1, adapter protein containing PH domain, PTB domain and leucine zipper motif 1; Arf6, ADP ribosylation factor 6; PIP5KL1, phosphatidylinositol-4-phosphate 5-kinase-like 1; SYNJ2, synaptojanin-2; RAC1, Ras-related C3 botulinum toxin substrate 1; RhoA, transforming protein RhoA; IP3R, inositol 1,4,5-trisphosphate receptor type 1; AHCYL1, putative adenosylhomocysteinase 2; SLC9A1, Na/H exchanger 1 (NHE-1) (solute carrier family 9 member 1); ARHGDIA, Rho GDP dissociation inhibitor 1 (Rho GDI 1); ARHGDIB, Rho GDP dissociation inhibitor 2 (Rho GDI 2); PIK3R1, phosphatidylinositol 3-kinase regulatory alpha subunit; EZR, Ezrin; SLC4A8, solute carrier family 4, sodium bicarbonate cotransporter, member 8; SLC9A3R1, Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1); SLC9A3R2, Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2); PLCB1, phospholipase C-beta-1; ACTA1, alpha actin 1; ACTC, alpha cardiac actin.