Temporal progression of hypothalamic patterning by a dual action of BMP - PubMed (original) (raw)

. 2008 Oct;135(20):3325-31.

doi: 10.1242/dev.027078. Epub 2008 Sep 11.

Affiliations

• PMID: 18787065
• DOI: 10.1242/dev.027078

Temporal progression of hypothalamic patterning by a dual action of BMP

Kyoji Ohyama et al. Development. 2008 Oct.

Abstract

In the developing chick hypothalamus, Shh and BMPs are expressed in a spatially overlapping, but temporally consecutive, manner. Here, we demonstrate how the temporal integration of Shh and BMP signalling leads to the late acquisition of Pax7 expression in hypothalamic progenitor cells. Our studies reveal a requirement for a dual action of BMPs: first, the inhibition of GliA function through Gli3 upregulation; and second, activation of a Smad5-dependent BMP pathway. Previous studies have shown a requirement for spatial antagonism of Shh and BMPs in early CNS patterning; here, we propose that neural pattern elaboration can be achieved through a versatile temporal antagonism between Shh and BMPs.

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