CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis - PubMed (original) (raw)

. 2008 Dec 15;112(13):5026-36.

doi: 10.1182/blood-2008-06-162404. Epub 2008 Sep 17.

Catriona A Ford, Marta Pasikowska, John D Pound, Sarah J Wilkinson, Ingrid E Dumitriu, Lynsey Melville, Lauren A Melrose, Carol Anne Ogden, Robert Nibbs, Gerard Graham, Christophe Combadiere, Christopher D Gregory

Affiliations

• PMID: 18799722
• DOI: 10.1182/blood-2008-06-162404

Free article

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Lucy A Truman et al. Blood. 2008.

Free article

Abstract

Cells undergoing apoptosis are efficiently located and engulfed by phagocytes. The mechanisms by which macrophages, the professional scavenging phagocytes of apoptotic cells, are attracted to sites of apoptosis are poorly defined. Here we show that CX3CL1/fractalkine, a chemokine and intercellular adhesion molecule, is released rapidly from apoptotic lymphocytes, via caspase- and Bcl-2-regulated mechanisms, to attract macrophages. Effective chemotaxis of macrophages to apoptotic lymphocytes is dependent on macrophage fractalkine receptor, CX3CR1. CX3CR1 deficiency caused diminished recruitment of macrophages to germinal centers of lymphoid follicles, sites of high-rate B-cell apoptosis. These results provide the first demonstration of chemokine/chemokine-receptor activity in the navigation of macrophages toward apoptotic cells and identify a mechanism by which macrophage infiltration of tissues containing apoptotic lymphocytes is achieved.

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