Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice - PubMed (original) (raw)
Comparative Study
Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice
H Koseki et al. Proc Natl Acad Sci U S A. 1991.
Abstract
A distinctive variable region 14-positive (V14+) alpha chain (V alpha 14+) of the T-cell antigen receptor is predominantly expressed in multiple mouse subspecies. The V alpha 14 family has two members, V alpha 14.1 and V alpha 14.2, which differ by only three amino acids at positions 50-52. Based on the EcoRI restriction fragment length polymorphism of the gene encoding V alpha 14, mice can be divided into three groups: type I with an 11.2-kilobase (kb) fragment, type II with a 2.0-kb fragment, and type III with the 2.0-kb and 11.2-kb fragments. Usage of V alpha 14-J alpha 281, where J alpha 281 is an alpha-chain joining segment, with a one-base N region dominates at the level of 0.02-1.5% of alpha chains in all laboratory strains, Mus musculus castaneus, and Mus musculus domesticus but not in Mus musculus molossinus, Mus musculus musculus, and Mus spicilegus samples. The preferential V alpha 14-J alpha 281 expression seems to be due to positive selection because the V-J junctional region is always glycine, despite the ability of the V alpha 14 gene to associate with J alpha other than J alpha 281. As V alpha 14-J alpha 281 expression is independent of known major histocompatibility complex antigens, including H-2, TLA, Qa, and HMT, the selecting ligand must be a monomorphic molecule of the mouse, expressed in a subspecies-specific manner. Additional observations, such as the expression of homogeneous V alpha 14-J alpha 281 in athymic mice, suggest that the positive selection of V alpha 14+ T cells occurs extrathymically.
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References
- Nature. 1989 Oct 26;341(6244):746-9 - PubMed
- EMBO J. 1989 Dec 1;8(12):3749-57 - PubMed
- Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:563-9 - PubMed
- Cell. 1989 Dec 1;59(5):859-70 - PubMed
- Proc Natl Acad Sci U S A. 1989 Aug;86(15):5928-32 - PubMed
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