Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders - PubMed (original) (raw)

Review

. 2009 May;23(5):597-602.

doi: 10.1002/ptr.2625.

Affiliations

• PMID: 18844286
• DOI: 10.1002/ptr.2625

Review

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders

Caterina Scuderi et al. Phytother Res. 2009 May.

Abstract

Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders.

PubMed Disclaimer

Similar articles

• Phytocannabinoids as novel therapeutic agents in CNS disorders.
  Hill AJ, Williams CM, Whalley BJ, Stephens GJ. Hill AJ, et al. Pharmacol Ther. 2012 Jan;133(1):79-97. doi: 10.1016/j.pharmthera.2011.09.002. Epub 2011 Sep 6. Pharmacol Ther. 2012. PMID: 21924288 Review.
• Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents.
  Fasinu PS, Phillips S, ElSohly MA, Walker LA. Fasinu PS, et al. Pharmacotherapy. 2016 Jul;36(7):781-96. doi: 10.1002/phar.1780. Pharmacotherapy. 2016. PMID: 27285147 Review.
• Neuroprotective potential of cannabidiol: Molecular mechanisms and clinical implications.
  Tambe SM, Mali S, Amin PD, Oliveira M. Tambe SM, et al. J Integr Med. 2023 May;21(3):236-244. doi: 10.1016/j.joim.2023.03.004. Epub 2023 Mar 18. J Integr Med. 2023. PMID: 36973157 Review.
• Cannabidiol--recent advances.
  Mechoulam R, Peters M, Murillo-Rodriguez E, Hanus LO. Mechoulam R, et al. Chem Biodivers. 2007 Aug;4(8):1678-92. doi: 10.1002/cbdv.200790147. Chem Biodivers. 2007. PMID: 17712814 Review.
• The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent.
  Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R. Murillo-Rodríguez E, et al. Behav Neurosci. 2008 Dec;122(6):1378-82. doi: 10.1037/a0013278. Behav Neurosci. 2008. PMID: 19045957

Cited by

• Is cannabidiol (CBD) effective to ease separation anxiety?
  Masataka N. Masataka N. Heliyon. 2024 Feb 5;10(3):e25851. doi: 10.1016/j.heliyon.2024.e25851. eCollection 2024 Feb 15. Heliyon. 2024. PMID: 38356586 Free PMC article.
• Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers.
  Masataka N. Masataka N. Heliyon. 2024 Jan 30;10(3):e25548. doi: 10.1016/j.heliyon.2024.e25548. eCollection 2024 Feb 15. Heliyon. 2024. PMID: 38322918 Free PMC article.
• Cannabidiol as a potential cessation therapeutic: Effects on intravenous nicotine self-administration and withdrawal symptoms in mice.
  Cheeks SN, Buzzi B, Valdez A, Mogul AS, Damaj MI, Fowler CD. Cheeks SN, et al. Neuropharmacology. 2024 Mar 15;246:109833. doi: 10.1016/j.neuropharm.2023.109833. Epub 2024 Jan 3. Neuropharmacology. 2024. PMID: 38176534 Free PMC article.
• Granite dust application to hemp - variety-specific impacts on growth and cannabinoid production.
  Hillier NK, Voscort L, Zamlynny L, Hillier W, Faraone N. Hillier NK, et al. Sci Rep. 2023 Dec 14;13(1):22254. doi: 10.1038/s41598-023-49529-9. Sci Rep. 2023. PMID: 38097701 Free PMC article.
• In Situ Gelling Hydroxypropyl Cellulose Formulation Comprising Cannabidiol-Loaded Block Copolymer Micelles for Sustained Drug Delivery.
  Kamenova K, Momekova D, Grancharov G, Prancheva A, Toncheva-Moncheva N, Ivanov E, Konstantinov S, Petrov PD. Kamenova K, et al. Int J Mol Sci. 2023 Nov 20;24(22):16534. doi: 10.3390/ijms242216534. Int J Mol Sci. 2023. PMID: 38003722 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations