Increased plasma free tryptophan levels in human cancer: a tumor related effect? - PubMed (original) (raw)
. 1991 May-Jun;11(3):1313-6.
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- PMID: 1888165
Increased plasma free tryptophan levels in human cancer: a tumor related effect?
A Cascino et al. Anticancer Res. 1991 May-Jun.
Abstract
High free tryptophan (F-TRP) plasma levels are found in cancer patients (CP). F-TRP plasma concentrations are affected by the levels of its carrier, albumin (ALB), and free fatty acids (FFA) competing with TRP for ALB binding sites. The lack of correlation between F-TRP, ALB and FFA in CP suggests a tumor-dependent effect on the rise in F-TRP. To verify this hypothesis, F-TRP, ALB and FFA levels were assayed in 12 lung and 16 breast CP susceptible to radical surgery, before and 15 days after surgical removal of the tumor. F-TRP levels significantly decreased after tumor ablation. Since no correlation was found between F-TRP, ALB and FFA variations, it is conceivable that the tumor itself may be responsible for the high F-TRP levels in CP.
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