Expression patterns of the lysophospholipid receptor genes during mouse early development - PubMed (original) (raw)

. 2008 Nov;237(11):3280-94.

doi: 10.1002/dvdy.21736.

Affiliations

• PMID: 18924241
• DOI: 10.1002/dvdy.21736

Free article

Expression patterns of the lysophospholipid receptor genes during mouse early development

Hideyo Ohuchi et al. Dev Dyn. 2008 Nov.

Free article

Abstract

Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis.

Copyright (c) 2008 Wiley-Liss, Inc.

PubMed Disclaimer

Similar articles

• Cell surface receptors in lysophospholipid signaling.
  Anliker B, Chun J. Anliker B, et al. Semin Cell Dev Biol. 2004 Oct;15(5):457-65. doi: 10.1016/j.semcdb.2004.05.005. Semin Cell Dev Biol. 2004. PMID: 15271291 Review.
• Non-Edg family lysophosphatidic acid (LPA) receptors.
  Ishii S, Noguchi K, Yanagida K. Ishii S, et al. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. doi: 10.1016/j.prostaglandins.2009.06.001. Epub 2009 Jun 12. Prostaglandins Other Lipid Mediat. 2009. PMID: 19524700 Review.
• A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors.
  Wang DA, Lorincz Z, Bautista DL, Liliom K, Tigyi G, Parrill AL. Wang DA, et al. J Biol Chem. 2001 Dec 28;276(52):49213-20. doi: 10.1074/jbc.M107301200. Epub 2001 Oct 16. J Biol Chem. 2001. PMID: 11604399
• Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells.
  Brünnert D, Sztachelska M, Bornkessel F, Treder N, Wolczynski S, Goyal P, Zygmunt M. Brünnert D, et al. Mol Hum Reprod. 2014 Oct;20(10):1016-25. doi: 10.1093/molehr/gau051. Epub 2014 Jul 3. Mol Hum Reprod. 2014. PMID: 24994816
• Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.
  Itoh R, Miura S, Takimoto A, Kondo S, Sano H, Hiraki Y. Itoh R, et al. J Bone Miner Metab. 2010 Nov;28(6):659-71. doi: 10.1007/s00774-010-0184-1. Epub 2010 May 11. J Bone Miner Metab. 2010. PMID: 20458606

Cited by

• Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain.
  Lin ME, Rivera RR, Chun J. Lin ME, et al. J Biol Chem. 2012 May 18;287(21):17608-17617. doi: 10.1074/jbc.M111.330183. Epub 2012 Mar 29. J Biol Chem. 2012. PMID: 22461625 Free PMC article.
• An Update on Sphingosine-1-Phosphate and Lysophosphatidic Acid Receptor Transcripts in Rodent Olfactory Mucosa.
  Toebbe JT, Genter MB. Toebbe JT, et al. Int J Mol Sci. 2022 Apr 14;23(8):4343. doi: 10.3390/ijms23084343. Int J Mol Sci. 2022. PMID: 35457160 Free PMC article.
• Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.
  Valdés-Rives SA, González-Arenas A. Valdés-Rives SA, et al. Mediators Inflamm. 2017;2017:9173090. doi: 10.1155/2017/9173090. Epub 2017 Dec 21. Mediators Inflamm. 2017. PMID: 29430083 Free PMC article. Review.
• Identification of cardiac hemo-vascular precursors and their requirement of sphingosine-1-phosphate receptor 1 for heart development.
  Hu Y, Belyea BC, Li M, Göthert JR, Gomez RA, Sequeira-Lopez ML. Hu Y, et al. Sci Rep. 2017 Mar 24;7:45205. doi: 10.1038/srep45205. Sci Rep. 2017. PMID: 28338096 Free PMC article.
• Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
  Gardner NM, Riley RT, Showker JL, Voss KA, Sachs AJ, Maddox JR, Gelineau-van Waes JB. Gardner NM, et al. Toxicol Sci. 2016 Mar;150(1):161-8. doi: 10.1093/toxsci/kfv321. Epub 2015 Dec 29. Toxicol Sci. 2016. PMID: 26719367 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Guide to Pharmacology
  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal