Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10 - PubMed (original) (raw)

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Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10

Joel Gelernter et al. Biol Psychiatry. 2009.

Abstract

Background: Alcohol dependence (AD) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci in several populations have been identified with genetic linkage analysis. To date, there has been no published linkage study of AD focused on African Americans (AAs).

Methods: We completed a genomewide linkage scan with approximately 6000 single nucleotide polymorphism markers to map loci increasing risk for DSM-IV AD in a set of 238 small nuclear families ascertained on the basis of multiple individuals affected with cocaine or opioid dependence. Model free linkage analysis was completed with Merlin software. A modified marker set was used to avoid bias due to markers in strong linkage disequilibrium.

Results: We identified a genomewide-significant linkage to markers near 117.2 centiMorgans on chromosome 10q23.3-24.1 (logarithm of odds score 3.32; p = 5.0E-05; empirical genomewide p = .033).

Conclusions: These data add to the growing evidence for locations for AD risk loci and provide the first linkage evidence for such a locus in the AA population.

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Figures

Figure 1

Figure 1

Chromosome 10 linkage results. LOD, logarithm of odds.

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References

    1. Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ. A population-based twin study of alcoholism in women. JAMA. 1992;268:1877–1882. - PubMed
    1. Kendler KS, Prescott CA, Neale MC, Pedersen NL. Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Arch Gen Psychiatry. 1997;54:178–184. - PubMed
    1. Prescott CA, Kendler KS. Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry. 1999;56:34–40. - PubMed
    1. Whitfield JB, Zhu G, Madden PA, Neale MC, Heath AC, Martin NG. The Genetics of Alcohol Intake and of Alcohol Dependence. Alcoholism: Clin Exp Res. 2004;8:1153–1160. - PubMed
    1. Hasin DS, Stinson FS, Ogburn E, Grant BF. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2007;64:830–842. - PubMed

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