Primary structure and expression of bovine poly(A) polymerase - PubMed (original) (raw)
Comparative Study
. 1991 Sep 19;353(6341):229-34.
doi: 10.1038/353229a0.
Affiliations
- PMID: 1896071
- DOI: 10.1038/353229a0
Comparative Study
Primary structure and expression of bovine poly(A) polymerase
T Raabe et al. Nature. 1991.
Abstract
Poly(A) polymerase has a critical role in the synthesis of messenger RNA in eukaryotic cells. The isolation and characterization of complementary DNAs encoding bovine poly(A) polymerase is described here. The predicted sequences of the mRNA and protein reveal features that provide insights into how the enzyme functions and how it might be regulated. Poly(A) polymerase expressed from a cloned cDNA is fully functional in in vitro assays, and mutational analyses have identified a putative regulatory domain that enhances, but is not essential for, activity.
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