Chemical engineering of mesenchymal stem cells to induce a cell rolling response - PubMed (original) (raw)
. 2008 Nov 19;19(11):2105-9.
doi: 10.1021/bc800345q.
Affiliations
- PMID: 18973352
- DOI: 10.1021/bc800345q
Chemical engineering of mesenchymal stem cells to induce a cell rolling response
Debanjan Sarkar et al. Bioconjug Chem. 2008.
Abstract
Covalently conjugated sialyl Lewis X (SLeX) on the mesenchymal stem cell (MSC) surface through a biotin-streptavidin bridge imparts leukocyte-like rolling characteristics without altering the cell phenotype and the multilineage differentiation potential. We demonstrate that the conjugation of SLeX on the MSC surface is stable, versatile, and induces a robust rolling response on P-selectin coated substrates. These results indicate the potential to increase the targeting efficiency of any cell type to specific tissue.
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