Is Sialyl Lewis x antigen expression a prognostic factor in patients with breast cancer? - PubMed (original) (raw)
Is Sialyl Lewis x antigen expression a prognostic factor in patients with breast cancer?
Prisca Sozzani et al. Int J Surg Pathol. 2008 Oct.
Abstract
Sialyl Lewis x (sLex) carbohydrate antigen acts as an adhesion molecule expressed on the surface of cancer cells and is the most important ligand of the selectins present on endothelial cells. sLex expression was correlated to the metastatic potential of breast cancer. The aim of the present work was to evaluate the prognostic value of sLex in a series of breast carcinomas with long-term follow-up. A total of 127 consecutive patients with primary breast cancer were enrolled and followed for a median of 140 months. Tumor grade, mitotic index, histotype, vascular invasion, and tumor extension and sLex were recorded and used in multivariate analysis. sLex antigen was expressed in 37 specimens (21%). Survival was similar for sLex-positive and sLex-negative tumors (62% vs 60%) for overall survival and for disease-free survival (59% vs 56%). Expression of sLex antigen in breast cancer is not associated with breast cancer survival.
Similar articles
- Expression of sialyl lewis X, sialyl Lewis A, E-cadherin and cathepsin-D in human breast cancer: immunohistochemical analysis in mammary carcinoma in situ, invasive carcinomas and their lymph node metastasis.
Jeschke U, Mylonas I, Shabani N, Kunert-Keil C, Schindlbeck C, Gerber B, Friese K. Jeschke U, et al. Anticancer Res. 2005 May-Jun;25(3A):1615-22. Anticancer Res. 2005. PMID: 16033070 - Expression of ABH/Lewis-related antigens as prognostic factors in patients with breast cancer.
Nakagoe T, Fukushima K, Itoyanagi N, Ikuta Y, Oka T, Nagayasu T, Ayabe H, Hara S, Ishikawa H, Minami H. Nakagoe T, et al. J Cancer Res Clin Oncol. 2002 May;128(5):257-64. doi: 10.1007/s00432-002-0334-5. Epub 2002 Mar 9. J Cancer Res Clin Oncol. 2002. PMID: 12029441 - Expression of carbohydrate antigens in advanced-stage ovarian carcinomas and their metastases-A clinicopathologic study.
Davidson B, Gotlieb WH, Ben-Baruch G, Kopolovic J, Goldberg I, Nesland JM, Berner A, Bjåmer A, Bryne M. Davidson B, et al. Gynecol Oncol. 2000 Apr;77(1):35-43. doi: 10.1006/gyno.1999.5708. Gynecol Oncol. 2000. PMID: 10739688 - Sialyl Lewis(a): a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells.
Ugorski M, Laskowska A. Ugorski M, et al. Acta Biochim Pol. 2002;49(2):303-11. Acta Biochim Pol. 2002. PMID: 12362971 Review. - Loss of Bcl-2 expression in colon cancer: a prognostic factor for recurrence in stage II colon cancer.
Poincloux L, Durando X, Seitz JF, Thivat E, Bardou VJ, Giovannini MH, Parriaux D, Barriere N, Giovannini M, Delpero JR, Monges G. Poincloux L, et al. Surg Oncol. 2009 Dec;18(4):357-65. doi: 10.1016/j.suronc.2008.09.003. Epub 2008 Nov 21. Surg Oncol. 2009. PMID: 19027288 Review.
Cited by
- Role of tumor cell sialylation in pancreatic cancer progression.
Marciel MP, Haldar B, Hwang J, Bhalerao N, Bellis SL. Marciel MP, et al. Adv Cancer Res. 2023;157:123-155. doi: 10.1016/bs.acr.2022.07.003. Epub 2022 Sep 27. Adv Cancer Res. 2023. PMID: 36725107 Free PMC article. Review. - Prognostic and Therapeutic Role of CD15 and CD15s in Cancer.
Szlasa W, Wilk K, Knecht-Gurwin K, Gurwin A, Froń A, Sauer N, Krajewski W, Saczko J, Szydełko T, Kulbacka J, Małkiewicz B. Szlasa W, et al. Cancers (Basel). 2022 Apr 28;14(9):2203. doi: 10.3390/cancers14092203. Cancers (Basel). 2022. PMID: 35565333 Free PMC article. Review. - sLex expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator.
Song Y, Sun H, Wu K, Lyu J, Zhang J, Gu F, Ma Y, Shen B, Wang C, Chen X, Xu J, Li W, Liu F, Fu L. Song Y, et al. Cancer Biol Med. 2021 Apr 24;18(2):477-89. doi: 10.20892/j.issn.2095-3941.2020.0422. Online ahead of print. Cancer Biol Med. 2021. PMID: 33893728 Free PMC article. - Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer.
Mehmeti-Ajradini M, Bergenfelz C, Larsson AM, Carlsson R, Riesbeck K, Ahl J, Janols H, Wullt M, Bredberg A, Källberg E, Björk Gunnarsdottir F, Rydberg Millrud C, Rydén L, Paul G, Loman N, Adolfsson J, Carneiro A, Jirström K, Killander F, Bexell D, Leandersson K. Mehmeti-Ajradini M, et al. Life Sci Alliance. 2020 Sep 21;3(11):e202000893. doi: 10.26508/lsa.202000893. Print 2020 Nov. Life Sci Alliance. 2020. PMID: 32958605 Free PMC article. - The physiological and pathological roles and applications of sialyl Lewis x, a common carbohydrate ligand of the three selectins.
Jin F, Wang F. Jin F, et al. Glycoconj J. 2020 Apr;37(2):277-291. doi: 10.1007/s10719-020-09912-4. Epub 2020 Feb 15. Glycoconj J. 2020. PMID: 32062824 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical