Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle - PubMed (original) (raw)

Review

. 2008 Aug;389(8):1037-41.

doi: 10.1515/BC.2008.110.

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• PMID: 18979628
• DOI: 10.1515/BC.2008.110

Review

Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle

Elena Roza Motrescu et al. Biol Chem. 2008 Aug.

Abstract

This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.

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