G2Cdb: the Genes to Cognition database - PubMed (original) (raw)

. 2009 Jan;37(Database issue):D846-51.

doi: 10.1093/nar/gkn700. Epub 2008 Nov 4.

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G2Cdb: the Genes to Cognition database

Mike D R Croning et al. Nucleic Acids Res. 2009 Jan.

Abstract

Neuroscience databases linking genes, proteins, (patho)physiology, anatomy and behaviour across species will be valuable in a broad range of studies of the nervous system. G2Cdb is such a neuroscience database aiming to present a global view of the role of synapse proteins in physiology and disease. G2Cdb warehouses sets of genes and proteins experimentally elucidated by proteomic mass spectroscopy of signalling complexes and proteins biochemically isolated from mammalian synapse preparations, giving an experimentally validated definition of the constituents of the mammalian synapse. Using automated text-mining and expert (human) curation we have systematically extracted information from published neurobiological studies in the fields of synaptic signalling electrophysiology and behaviour in knockout and other transgenic mice. We have also surveyed the human genetics literature for associations to disease caused by mutations in synaptic genes. The synapse proteome datasets that G2Cdb provides offer a basis for future work in synapse biology and provide useful information on brain diseases. They have been integrated in a such way that investigators can rapidly query whether a gene or protein is found in brain-signalling complex(es), has a phenotype in rodent models or whether mutations are associated with a human disease. G2Cdb can be freely accessed at http://www.genes2cognition.org.

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Figures

Figure 1.

Figure 1.

Sample screenshots of G2Cdb. Searching for SAP102 (A) returns links to the G2Cdb ‘GeneView’ pages for both the mouse (B) and human genes with their species-specific links to external resources. Also returned are curated results from two human genetics studies (C) that have linked mutations in the gene encoding SAP102 (DLG3) to X-linked mental retardation (D), as is data extracted from a published knockout mouse study. The gene list comparison tool is also shown, displaying the results of comparing the mouse PSD and PSP datasets (E).

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