The sequential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1 - PubMed (original) (raw)
Comparative Study
. 1991 Jan 15;146(2):677-84.
Affiliations
- PMID: 1898960
Comparative Study
The sequential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1
P D Collins et al. J Immunol. 1991.
Abstract
An in vivo experimental peritonitis model was investigated in the rabbit using zymosan as the inflammatory stimulus. After an i.p. injection of zymosan, exudate was removed at intervals and tested in the back skin of assay rabbits. Assay rabbits received i.v. injections of 125I-albumin and 111In-neutrophils, and the local accumulation of each label was measured in response to intradermal injections of exudate samples mixed with a potentiating dose of PGE2. When peritoneal exudate samples were tested in the presence of a specific anti-C5a antibody, virtually all the edema-inducing and neutrophil chemoattractant activity was abolished in samples taken up to 2 h after the zymosan injection. Later samples, however, contained increasing levels of a non-C5a component. In C5a-depleted 6-h exudate two peaks of inflammatory activity were separated using cation exchange HPLC. Evidence is presented that C5a itself is unable to stimulate the production of these activities. Both peaks of activity appear related to IL-8/NAP-1 as they inhibited the binding of 125I-IL-8/NAP-1 to human neutrophils.
Similar articles
- Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.
Ivey CL, Williams FM, Collins PD, Jose PJ, Williams TJ. Ivey CL, et al. J Clin Invest. 1995 Jun;95(6):2720-8. doi: 10.1172/JCI117974. J Clin Invest. 1995. PMID: 7769111 Free PMC article. - Neutrophil attractant/activation protein-1 (NAP-1 [interleukin-8]).
Leonard EJ, Yoshimura T. Leonard EJ, et al. Am J Respir Cell Mol Biol. 1990 Jun;2(6):479-86. doi: 10.1165/ajrcmb/2.6.479. Am J Respir Cell Mol Biol. 1990. PMID: 2189453 Review. - Polypeptide neutrophil chemoattractants in the skin.
Camp RD. Camp RD. Dermatologica. 1989;179 Suppl 1:20-4. doi: 10.1159/000248443. Dermatologica. 1989. PMID: 2673854 Review.
Cited by
- Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1.
Allcock GH, Allegra M, Flower RJ, Perretti M. Allcock GH, et al. Clin Exp Immunol. 2001 Jan;123(1):62-7. doi: 10.1046/j.1365-2249.2001.01370.x. Clin Exp Immunol. 2001. PMID: 11167999 Free PMC article. - Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators.
Teixeira MM, Fairbairn SM, Norman KE, Williams TJ, Rossi AG, Hellewell PG. Teixeira MM, et al. Br J Pharmacol. 1994 Dec;113(4):1363-71. doi: 10.1111/j.1476-5381.1994.tb17148.x. Br J Pharmacol. 1994. PMID: 7889293 Free PMC article. - Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis.
Steil AA, Garcia Rodriguez MC, Alonso A, Crespo MS, Bosca L. Steil AA, et al. Br J Pharmacol. 1995 Feb;114(4):895-901. doi: 10.1111/j.1476-5381.1995.tb13288.x. Br J Pharmacol. 1995. PMID: 7539698 Free PMC article. - Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection.
Saederup N, Aguirre SA, Sparer TE, Bouley DM, Mocarski ES. Saederup N, et al. J Virol. 2001 Oct;75(20):9966-76. doi: 10.1128/JVI.75.20.9966-9976.2001. J Virol. 2001. PMID: 11559829 Free PMC article. - Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichloromethylene diphosphonate.
van Lent PL, van den Bersselaar L, van den Hoek AE, van de Ende M, Dijkstra CD, van Rooijen N, van de Putte LB, van den Berg WB. van Lent PL, et al. Rheumatol Int. 1993;13(1):21-30. doi: 10.1007/BF00290330. Rheumatol Int. 1993. PMID: 8516620
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials