Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies - PubMed (original) (raw)
Meta-Analysis
. 2008 Nov;88(5):1419-37.
doi: 10.3945/ajcn.2007.25700.
Affiliations
- PMID: 18996880
- DOI: 10.3945/ajcn.2007.25700
Free article
Meta-Analysis
Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies
Geoffrey Livesey et al. Am J Clin Nutr. 2008 Nov.
Free article
Abstract
Background: The glycemic response to dietary fructose is low, which may improve concentrations of glycated hemoglobin (HbA(1c), a marker of dysglycemia). Meanwhile, adverse effects on plasma triacylglycerol (a marker of dyslipidemia) and body weight have been questioned. Such effects are reported inconsistently.
Objective: We aimed to evaluate the effect of fructose on these health markers, particularly examining treatment dose and duration, and level of glycemic control.
Design: A literature search was conducted for relevant randomized and controlled intervention studies of crystalline or pure fructose (excluding high-fructose corn syrup), data extraction, meta-analyses, and modeling using meta-regression.
Results: Fructose intake < 90 g/d significantly improved HbA(1c) concentrations dependent on the dose, the duration of study, and the continuous severity of dysglycemia throughout the range of dysglycemia. There was no significant change in body weight at intakes <100 g fructose/d. Fructose intakes of <50 g/d had no postprandially significant effect on triacylglycerol and those of <or=100g/d had no significant effect when subjects were fasting. At >or=100 g fructose/d, the effect on fasting triacylglycerol depended on whether sucrose or starch was being exchanged with fructose, and the effect was dose-dependent but was less with increasing duration of treatment. Different health types and sources of bias were examined; they showed no significant departure from a general trend.
Conclusions: The meta-analysis shows that fructose intakes from 0 to >or=90 g/d have a beneficial effect on HbA(1c). Significant effects on postprandial triacylglycerols are not evident unless >50 g fructose/d is consumed, and no significant effects are seen for fasting triacylglycerol or body weight with intakes of <or=100 g fructose/d in adults.
Comment in
- How safe is fructose for persons with or without diabetes?
Sánchez-Lozada LG, Le M, Segal M, Johnson RJ. Sánchez-Lozada LG, et al. Am J Clin Nutr. 2008 Nov;88(5):1189-90. doi: 10.3945/ajcn.2008.26812. Am J Clin Nutr. 2008. PMID: 18996851 No abstract available.
Similar articles
- Chronic fructose substitution for glucose or sucrose in food or beverages has little effect on fasting blood glucose, insulin, or triglycerides: a systematic review and meta-analysis.
Evans RA, Frese M, Romero J, Cunningham JH, Mills KE. Evans RA, et al. Am J Clin Nutr. 2017 Aug;106(2):519-529. doi: 10.3945/ajcn.116.145169. Epub 2017 Jun 7. Am J Clin Nutr. 2017. PMID: 28592603 Review. - Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup.
Stanhope KL, Havel PJ. Stanhope KL, et al. Am J Clin Nutr. 2008 Dec;88(6):1733S-1737S. doi: 10.3945/ajcn.2008.25825D. Am J Clin Nutr. 2008. PMID: 19064538 Free PMC article. Review. - A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans.
Lê KA, Faeh D, Stettler R, Ith M, Kreis R, Vermathen P, Boesch C, Ravussin E, Tappy L. Lê KA, et al. Am J Clin Nutr. 2006 Dec;84(6):1374-9. doi: 10.1093/ajcn/84.6.1374. Am J Clin Nutr. 2006. PMID: 17158419 Clinical Trial. - Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P. Crider K, et al. Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database Syst Rev. 2022. PMID: 36321557 Free PMC article.
Cited by
- The Therapeutic Potential of the Specific Intestinal Microbiome (SIM) Diet on Metabolic Diseases.
Chu NHS, Chow E, Chan JCN. Chu NHS, et al. Biology (Basel). 2024 Jul 4;13(7):498. doi: 10.3390/biology13070498. Biology (Basel). 2024. PMID: 39056692 Free PMC article. Review. - Nutrient quality in dietary therapy for diabetes and diabetic kidney disease.
Tsuruta H, Sugahara S, Kume S. Tsuruta H, et al. J Diabetes Investig. 2024 Aug;15(8):973-981. doi: 10.1111/jdi.14208. Epub 2024 Apr 9. J Diabetes Investig. 2024. PMID: 38591876 Free PMC article. Review. - Comprehensive Approach to Medical Nutrition Therapy in Patients with Type 2 Diabetes Mellitus: From Diet to Bioactive Compounds.
Barrea L, Vetrani C, Verde L, Frias-Toral E, Ceriani F, Cernea S, Docimo A, Graziadio C, Tripathy D, Savastano S, Colao A, Muscogiuri G. Barrea L, et al. Antioxidants (Basel). 2023 Apr 10;12(4):904. doi: 10.3390/antiox12040904. Antioxidants (Basel). 2023. PMID: 37107279 Free PMC article. Review. - Tolerable upper intake level for dietary sugars.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D, Bohn T, Castenmiller J, de Henauw S, Hirsch-Ernst KI, Knutsen HK, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Peláez C, Pentieva K, Siani A, Thies F, Tsabouri S, Adan R, Emmett P, Galli C, Kersting M, Moynihan P, Tappy L, Ciccolallo L, de Sesmaisons-Lecarré A, Fabiani L, Horvath Z, Martino L, Muñoz Guajardo I, Valtueña Martínez S, Vinceti M. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), et al. EFSA J. 2022 Feb 28;20(2):e07074. doi: 10.2903/j.efsa.2022.7074. eCollection 2022 Feb. EFSA J. 2022. PMID: 35251356 Free PMC article. - Nutritional Status, Selected Nutrients Intake and Their Relationship with the Concentration of Ghrelin and Adiponectin in Patients with Diabetic Nephropathy.
Boniecka I, Jeznach-Steinhagen A, Michalska W, Rymarz A, Szostak-Węgierek D, Niemczyk S. Boniecka I, et al. Nutrients. 2021 Dec 10;13(12):4416. doi: 10.3390/nu13124416. Nutrients. 2021. PMID: 34959967 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous