Preproenkephalin mRNA and methionine-enkephalin increase in mouse striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment - PubMed (original) (raw)
Preproenkephalin mRNA and methionine-enkephalin increase in mouse striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment
K P Gudehithlu et al. J Neurochem. 1991 Mar.
Abstract
Dopaminergic neurons that project to the striatum from the substantia nigra are thought to modulate methionine-enkephalin (Met-Enk) metabolism in the striatum. We administered a dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that produces a moderate depletion of dopamine in striatum, about 50%, without overt motor deficits, and found that Met-Enk-like immunoreactivity and preproenkephalin mRNA content increased in the tissue. Pretreatment with the monoamine oxidase B inhibitor deprenyl or the dopamine transport blocker nomifensine prevented these changes, suggesting that the changes were related to the partial loss of dopaminergic neurons rather than to MPTP. Moreover, administering GM1 ganglioside, which partially restores the MPTP-induced dopaminergic deficit, partially corrected the Met-Enk changes in the striatum as well. These findings are consistent with the hypothesis that dopaminergic input to the striatum, in part, modulates Met-Enk metabolism. Moreover, they show that moderate nigrostriatal lesions are sufficient to elevate Met-Enk and preproenkephalin mRNA contents and that restoration of dopaminergic function, as in our studies with GM1 ganglioside, restores the content of Met-Enk.
Similar articles
- Preproenkephalin mRNA and methionine-enkephalin content are increased in mouse striatum after treatment with nicotine.
Dhatt RK, Gudehithlu KP, Wemlinger TA, Tejwani GA, Neff NH, Hadjiconstantinou M. Dhatt RK, et al. J Neurochem. 1995 Apr;64(4):1878-83. doi: 10.1046/j.1471-4159.1995.64041878.x. J Neurochem. 1995. PMID: 7891117 - The effects of L-deprenyl treatment, alone and combined with GM1 ganglioside, on striatal dopamine content and substantia nigra pars compacta neurons.
Rothblat DS, Schneider JS. Rothblat DS, et al. Brain Res. 1998 Jan 1;779(1-2):226-30. doi: 10.1016/s0006-8993(97)01260-2. Brain Res. 1998. PMID: 9473679 - GM1 ganglioside-induced recovery of nigrostriatal dopaminergic neurons after MPTP: an immunohistochemical study.
Hadjiconstantinou M, Mariani AP, Neff NH. Hadjiconstantinou M, et al. Brain Res. 1989 Apr 10;484(1-2):297-303. doi: 10.1016/0006-8993(89)90373-9. Brain Res. 1989. PMID: 2565752 - [Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].
Sheng J. Sheng J. Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990 Apr;23(2):104-6, 127-8. Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990. PMID: 2118063 Chinese. - Met-enkephalin and preproenkephalin mRNA changes in the striatum of the nicotine abstinence mouse.
Isola R, Zhang H, Duchemin AM, Tejwani GA, Neff NH, Hadjiconstantinou M. Isola R, et al. Neurosci Lett. 2002 May 31;325(1):67-71. doi: 10.1016/s0304-3940(02)00240-9. Neurosci Lett. 2002. PMID: 12023068
Cited by
- Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting.
Song DD, Haber SN. Song DD, et al. J Neurosci. 2000 Jul 1;20(13):5102-14. doi: 10.1523/JNEUROSCI.20-13-05102.2000. J Neurosci. 2000. PMID: 10864967 Free PMC article. - Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.
Duty S, Jenner P. Duty S, et al. Br J Pharmacol. 2011 Oct;164(4):1357-91. doi: 10.1111/j.1476-5381.2011.01426.x. Br J Pharmacol. 2011. PMID: 21486284 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous