Nutritional regulation of glucagon-like peptide-1 secretion - PubMed (original) (raw)
Review
Nutritional regulation of glucagon-like peptide-1 secretion
Gwen Tolhurst et al. J Physiol. 2009.
Abstract
Glucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP-1 or preventing its degradation, attention is now turning towards the L-cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP-1 in vivo. Understanding the mechanisms underlying GLP-1 release from L-cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L-cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L-cell nutrient responsiveness.
Figures
Figure 1. A working model for nutrient-stimulated GLP-1 release
Upper panel: enteroendocrine cells in the intestinal epithelium (grey) detect nutrients passing in the lumen, but also respond to paracrine, neural and hormonal stimuli. Lower panel: potential nutrient-sensing pathways in an individual L-cell include electrogenic uptake pathways, such as SGLT1, metabolic closure of KATP channels and activation of G protein-coupled receptors (GPCRs). Downstream signalling pathways include elevated cAMP and [Ca2+], which stimulate vesicle fusion and the consequent release of GLP-1.
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References
- Abello J, Ye F, Bosshard A, Bernard C, Cuber JC, Chayvialle JA. Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line. Endocrinology. 1994;134:2011–2017. - PubMed
- Balks HJ, Holst JJ, von zur Mühlen A, Brabant G. Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: cholinergic control of GLP-1 secretion via muscarinic receptors. J Clin Endocrinol Metab. 1997;82:786–790. - PubMed
- Brubaker PL. Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures. Endocrinology. 1988;123:220–226. - PubMed
- Brubaker PL, Drucker DJ. Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology. 2004;145:2653–2659. - PubMed
- Brubaker PL, Schloos J, Drucker DJ. Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line. Endocrinology. 1998;139:4108–4114. - PubMed
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