Randomized controlled trial of calcium supplementation in healthy, nonosteoporotic, older men - PubMed (original) (raw)
Randomized Controlled Trial
. 2008 Nov 10;168(20):2276-82.
doi: 10.1001/archinte.168.20.2276.
Affiliations
- PMID: 19001206
- DOI: 10.1001/archinte.168.20.2276
Randomized Controlled Trial
Randomized controlled trial of calcium supplementation in healthy, nonosteoporotic, older men
Ian R Reid et al. Arch Intern Med. 2008.
Abstract
Background: There is no consistent evidence, to our knowledge, that calcium supplementation affects bone mineral density (BMD) in men, despite male osteoporosis being a common clinical problem.
Methods: To determine the effects of calcium supplementation (600 mg/d, 1200 mg/d, or placebo) on BMD in men, we conducted a double-blind, randomized controlled trial for a 2-year period at an academic clinical research center. A total of 323 healthy men at least 40 years old (mean age, 57 years) were recruited by newspaper advertisement. Complete follow-up was achieved in 96% of subjects.
Results: The BMD increased at all sites in the group receiving calcium, 1200 mg/d, by 1% to 1.5% more than those receiving placebo. The results for the group receiving calcium, 600 mg/d, were not different from the placebo group at any BMD site. There was no interaction between the BMD treatment effect and either age or dietary calcium intake. There were dosage-related, sustained decreases in serum parathyroid hormone (P < .001), total alkaline phosphatase activity (P = .01), and procollagen type 1 N-terminal propeptide (P < .001) amounting to 25%, 8%, and 20%, respectively, in the group receiving calcium, 1200 mg/d, at 2 years. Tooth loss, constipation, and cramps were unaffected by calcium supplementation, falls tended to be less frequent in the group receiving calcium, 1200 mg/d, but vascular events tended to be more common in the groups receiving calcium vs the group receiving placebo.
Conclusion: Calcium, 1200 mg/d, has effects on BMD in men comparable with those found in postmenopausal women but a dosage of 600 mg/d is ineffective for treating BMD.
Trial registration: actr.org.au Identifier: 012605000274673.
Comment in
- Can healthy, older, nonosteoporotic men benefit from calcium supplementation?
Lee C. Lee C. Curr Osteoporos Rep. 2009 Sep;7(3):73-4. doi: 10.1007/s11914-009-0019-y. Curr Osteoporos Rep. 2009. PMID: 19723464 No abstract available.
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