Depressive symptoms as predictors of mortality in patients with COPD - PubMed (original) (raw)
. 2009 Mar;135(3):619-625.
doi: 10.1378/chest.08-0078. Epub 2008 Nov 24.
Affiliations
- PMID: 19029432
- DOI: 10.1378/chest.08-0078
Free article
Depressive symptoms as predictors of mortality in patients with COPD
Jacob N de Voogd et al. Chest. 2009 Mar.
Free article
Abstract
Objective: Prognostic studies of mortality in patients with COPD have mostly focused on physiologic variables, with little attention to depressive symptoms. This stands in sharp contrast to the attention that depressive symptoms have been given in the outcomes of patients with other chronic health conditions. The present study investigated the independent association of depressive symptoms in stable patients with COPD with all-cause mortality.
Methods: The baseline characteristics of 121 COPD patients (78 men and 43 women; mean [+/- SD] age, 61.5 +/- 9.1 years; and mean FEV(1), 36.9 +/- 15.5% predicted) were collected on hospital admission to a pulmonary rehabilitation center. The data included demographic variables, body mass index (BMI), post-bronchodilator therapy FEV(1), and Wpeak (peak workload [Wpeak]). Depressive symptoms were assessed using the Beck depression inventory. The vital status was ascertained using municipal registrations. In 8.5 years of follow-up, 76 deaths occurred (mortality rate, 63%). Survival time ranged from 88 days to 8.5 years (median survival time, 5.3 years). The Cox proportional hazard model was used to quantify the association of the baseline characteristics (ie, age, sex, marital status, smoking behavior, FEV(1), BMI, Wpeak, and depressive symptoms) with mortality.
Results: Depressive symptoms (odds ratio [OR], 1.93; 95% confidence interval [CI], 1.12 to 3.33) were associated with mortality in patients with COPD, independent of other factors including male sex (OR, 1.73; 95% CI, 1.03 to 2.92), older age (OR, 1.05; 95% CI, 1.02 to 1.08), and lower Wpeak (OR, 0.98; 95% CI, 0.97 to 0.99).
Conclusions: This study provides evidence that depressive symptoms assessed in stable patients with COPD are associated with their subsequent all-cause mortality.
Similar articles
- Effect of depression care on outcomes in COPD patients with depression.
Jordan N, Lee TA, Valenstein M, Pirraglia PA, Weiss KB. Jordan N, et al. Chest. 2009 Mar;135(3):626-632. doi: 10.1378/chest.08-0839. Epub 2008 Nov 18. Chest. 2009. PMID: 19017894 - Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life.
Ng TP, Niti M, Tan WC, Cao Z, Ong KC, Eng P. Ng TP, et al. Arch Intern Med. 2007 Jan 8;167(1):60-7. doi: 10.1001/archinte.167.1.60. Arch Intern Med. 2007. PMID: 17210879 - Sex, depression, and risk of hospitalization and mortality in chronic obstructive pulmonary disease.
Fan VS, Ramsey SD, Giardino ND, Make BJ, Emery CF, Diaz PT, Benditt JO, Mosenifar Z, McKenna R Jr, Curtis JL, Fishman AP, Martinez FJ; National Emphysema Treatment Trial (NETT) Research Group. Fan VS, et al. Arch Intern Med. 2007 Nov 26;167(21):2345-53. doi: 10.1001/archinte.167.21.2345. Arch Intern Med. 2007. PMID: 18039994 Clinical Trial. - Mortality after hospitalization for COPD.
Almagro P, Calbo E, Ochoa de Echagüen A, Barreiro B, Quintana S, Heredia JL, Garau J. Almagro P, et al. Chest. 2002 May;121(5):1441-8. doi: 10.1378/chest.121.5.1441. Chest. 2002. PMID: 12006426 - Predictors of all-cause mortality in patients with stable COPD: medical co-morbid conditions or high depressive symptoms.
Maters GA, de Voogd JN, Sanderman R, Wempe JB. Maters GA, et al. COPD. 2014 Aug;11(4):468-74. doi: 10.3109/15412555.2014.898026. Epub 2014 May 15. COPD. 2014. PMID: 24831411
Cited by
- Advanced Chronic Obstructive Pulmonary Disease: Innovative and Integrated Management Approaches.
Zhou HX, Ou XM, Tang YJ, Wang L, Feng YL. Zhou HX, et al. Chin Med J (Engl). 2015 Nov 5;128(21):2952-9. doi: 10.4103/0366-6999.168073. Chin Med J (Engl). 2015. PMID: 26521796 Free PMC article. Review. No abstract available. - A multidisciplinary telehealth program in patients with combined chronic obstructive pulmonary disease and chronic heart failure: study protocol for a randomized controlled trial.
Bernocchi P, Scalvini S, Galli T, Paneroni M, Baratti D, Turla O, La Rovere MT, Volterrani M, Vitacca M. Bernocchi P, et al. Trials. 2016 Sep 22;17(1):462. doi: 10.1186/s13063-016-1584-x. Trials. 2016. PMID: 27659741 Free PMC article. - The Dyspnoea, Obstruction, Smoking, Exacerbation (DOSE) index is predictive of mortality in COPD.
Sundh J, Janson C, Lisspers K, Ställberg B, Montgomery S. Sundh J, et al. Prim Care Respir J. 2012 Sep;21(3):295-301. doi: 10.4104/pcrj.2012.00054. Prim Care Respir J. 2012. PMID: 22786813 Free PMC article. - Survival prediction in patients with chronic obstructive pulmonary disease following a pulmonary rehabilitation programme in Hong Kong.
Lau CW, Mok T, Ko WW, Ng BH, Chan IH, Tsui TT, Ling SO, Kwan HY, Poon YN, Yim CW, Yau PY. Lau CW, et al. Hong Kong J Occup Ther. 2019 Dec;32(2):108-117. doi: 10.1177/1569186119882772. Epub 2019 Nov 15. Hong Kong J Occup Ther. 2019. PMID: 32009862 Free PMC article. - Depressed mood predicts pulmonary rehabilitation completion among women, but not men.
Busch AM, Scott-Sheldon LA, Pierce J, Chattillion EA, Cunningham K, Buckley ML, Mazer JM, Blaney CL, Carey MP. Busch AM, et al. Respir Med. 2014 Jul;108(7):1007-13. doi: 10.1016/j.rmed.2014.04.010. Epub 2014 Apr 26. Respir Med. 2014. PMID: 24820243 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical