Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase - PubMed (original) (raw)
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase
M W Hentze et al. Nucleic Acids Res. 1991.
Free PMC article
Abstract
Iron-responsive elements (IREs) are regulatory RNA elements which serve as specific binding sites for the IRE-binding protein (IRE-BP). Interaction between IREs and IRE-BP induces repression of ferritin mRNA translation and transferrin receptor mRNA stabilization. We describe the identification of extensive amino acid sequence homology between IRE-BP and two known isomerases, aconitase and isopropylmalate (IPM) isomerase. We discuss the implications of this observation with regard to structure/function relationships of IRE-BP. The structural conservation between a regulatory RNA-binding protein and two enzymes involved in intermediary metabolism provides a surprising example of the functional flexibility in biological structures.
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References
- Biochemistry. 1963 Sep-Oct;2:1046-52 - PubMed
- Ann Hum Genet. 1976 May;39(4):413-22 - PubMed
- Comput Appl Biosci. 1990 Jul;6(3):279-88 - PubMed
- J Mol Biol. 1987 Jan 20;193(2):385-96 - PubMed
- Mol Cell Biol. 1989 Nov;9(11):5055-61 - PubMed
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