Molecular analysis of a human interferon-inducible gene family - PubMed (original) (raw)
Molecular analysis of a human interferon-inducible gene family
A R Lewin et al. Eur J Biochem. 1991.
Free article
Abstract
Three functional members of the 1-8 gene family have been isolated on a single human genomic DNA fragment of less than 18 kb. The 1-8U and 1-8D genes are extremely similar; each is contained within a less than 2-kb fragment, has in its 5'flanking region two adjacent 14-base-pair sequences showing high similarity to interferon-stimulable response elements (ISREs) and has two highly related exons. The third gene (9-27) has a similar overall structure, shows substantial similarity to the 1-8s but has only one ISRE which is 3' of two CCAAT boxes not present in the 1-8U and D genes. The cDNA corresponding to the three genes share 120 nucleotides of identical sequence and show greater than 90% identity over 70% of the coding sequence. For the 1-8U and D genes the high similarity extends into the 5' non-coding and flanking regions. The open reading frames encode polypeptides that are likely to be of very similar structure. Antiserum to a conserved peptide detects a polypeptide(s) of about 14 kDa on PAGE which separates into three components on isoelectric focussing. The 9-27 and 1-8U genes are highly interferon-inducible the 1-8D gene is much less so. These differences are mimicked by the activities of the corresponding ISREs placed 5' of a marker gene in expression constructs. They presumably reflect differences in the interaction of the ISREs with the various interferon-inducible and constitutive factors that govern the interferon response.
Similar articles
- A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
Reid LE, Brasnett AH, Gilbert CS, Porter AC, Gewert DR, Stark GR, Kerr IM. Reid LE, et al. Proc Natl Acad Sci U S A. 1989 Feb;86(3):840-4. doi: 10.1073/pnas.86.3.840. Proc Natl Acad Sci U S A. 1989. PMID: 2492664 Free PMC article. - Functional differences in the promoters of the interferon-inducible (2'-5')A oligoadenylate synthetase and 6-16 genes in interferon-resistant Daudi cells.
Guille MJ, Laxton CD, Rutherford MN, Williams BR, Kerr IM. Guille MJ, et al. Eur J Biochem. 1994 Jan 15;219(1-2):547-53. doi: 10.1111/j.1432-1033.1994.tb19970.x. Eur J Biochem. 1994. PMID: 8307020 - Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family.
Bluyssen HA, Vlietstra RJ, Faber PW, Smit EM, Hagemeijer A, Trapman J. Bluyssen HA, et al. Genomics. 1994 Nov 1;24(1):137-48. doi: 10.1006/geno.1994.1591. Genomics. 1994. PMID: 7896268 - The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors.
Parrington J, Rogers NC, Gewert DR, Pine R, Veals SA, Levy DE, Stark GR, Kerr IM. Parrington J, et al. Eur J Biochem. 1993 Jun 15;214(3):617-26. doi: 10.1111/j.1432-1033.1993.tb17961.x. Eur J Biochem. 1993. PMID: 7686487 - Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.
Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA. Benech PD, et al. J Exp Med. 1992 Oct 1;176(4):1115-23. doi: 10.1084/jem.176.4.1115. J Exp Med. 1992. PMID: 1402657 Free PMC article.
Cited by
- Role of Type I Interferons during Mycobacterium tuberculosis and HIV Infections.
Anes E, Azevedo-Pereira JM, Pires D. Anes E, et al. Biomolecules. 2024 Jul 14;14(7):848. doi: 10.3390/biom14070848. Biomolecules. 2024. PMID: 39062562 Free PMC article. Review. - Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer.
Wang P, Pan Y, Zhang Y, Chen C, Hu J, Wang X. Wang P, et al. Med Oncol. 2024 Mar 12;41(4):85. doi: 10.1007/s12032-024-02308-6. Med Oncol. 2024. PMID: 38472606 Review. - Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins.
Marceau T, Braibant M. Marceau T, et al. Viruses. 2024 Feb 5;16(2):254. doi: 10.3390/v16020254. Viruses. 2024. PMID: 38400030 Free PMC article. Review. - Influenza Virus Host Restriction Factors: The ISGs and Non-ISGs.
Husain M. Husain M. Pathogens. 2024 Jan 29;13(2):127. doi: 10.3390/pathogens13020127. Pathogens. 2024. PMID: 38392865 Free PMC article. Review. - The novel role of IFITM1-3 in myogenic differentiation of C2C12 cells.
Zhang Y, Lu Y, Li X, Zhang S, Liu P, Hao X, Han J. Zhang Y, et al. Intractable Rare Dis Res. 2023 Aug;12(3):180-190. doi: 10.5582/irdr.2023.01050. Intractable Rare Dis Res. 2023. PMID: 37662621 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases