ER stress and lipogenesis: a slippery slope toward hepatic steatosis - PubMed (original) (raw)

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ER stress and lipogenesis: a slippery slope toward hepatic steatosis

Sana Basseri et al. Dev Cell. 2008 Dec.

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Abstract

Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this issue of Developmental Cell,Rutkowski et al. (2008) show that unresolved ER stress contributes to metabolic dysfunction and hepatic steatosis.

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• UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.
  Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ. Rutkowski DT, et al. Dev Cell. 2008 Dec;15(6):829-40. doi: 10.1016/j.devcel.2008.10.015. Dev Cell. 2008. PMID: 19081072 Free PMC article.

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