Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain? - PubMed (original) (raw)

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Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

P Vandenabeele et al. Immunol Today. 1991 Jul.

Abstract

Alzheimer's disease is characterized by the presence of amyloid plaques in the brain, which comprise mainly beta-amyloid peptide and alpha 1-antichymotrypsin. Here, Peter Vandenabeele and Walter Fiers advance the hypothesis that this amyloidogenesis results from an IL-1-/IL-6-mediated acute phase reaction in the brain. They propose possible intracerebral sources of cytokines and acute phase proteins in microglia, astrocytes, neurons and cells of the choroid plexus.

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Comment in

• Cytokines and Alzheimer's disease.
  Chaldakov GN. Chaldakov GN. Immunol Today. 1992 Jun;13(6):237. doi: 10.1016/0167-5699(92)90162-Z. Immunol Today. 1992. PMID: 1627252 No abstract available.
• IL-6-mediated events in Alzheimer's disease pathology.
  Bauer J, Strauss S, Volk B, Berger M. Bauer J, et al. Immunol Today. 1991 Nov;12(11):422. doi: 10.1016/0167-5699(91)90148-M. Immunol Today. 1991. PMID: 1786076 No abstract available.

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