Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics - PubMed (original) (raw)
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Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics
F M Brodsky et al. Trends Biochem Sci. 1991 Jun.
Abstract
Polymerization of clathrin triskelions into clathrin coats and subsequent disassembly by the heat shock protein hsc70 control receptor-mediated pathways of intracellular transport. The clathrin light chains are major regulatory elements in these processes. These polypeptides consist of linear arrays of functional domains with distinctive sequence motifs. Comparison of unicellular and multicellular eukaryotes reveals differences in the numbers of clathrin light chains and in the functional domains they contain.
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