Annexin A1 and glucocorticoids as effectors of the resolution of inflammation - PubMed (original) (raw)

Review

doi: 10.1038/nri2470.

Affiliations

Review

Annexin A1 and glucocorticoids as effectors of the resolution of inflammation

Mauro Perretti et al. Nat Rev Immunol. 2009 Jan.

Abstract

Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical application stems from our understanding of the inhibitory effect of the corticosteroid hormone cortisol on several components of the immune system. Endogenous and exogenous glucocorticoids mediate their multiple anti-inflammatory effects through many effector molecules. In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in immune responses. In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8222-6 - PubMed
    1. Blood. 2003 Feb 15;101(4):1572-81 - PubMed
    1. J Immunol. 2007 Jan 1;178(1):436-45 - PubMed
    1. Blood. 2000 Mar 1;95(5):1810-8 - PubMed
    1. J Exp Med. 2006 Jan 23;203(1):7-13 - PubMed

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources