The burden of human African trypanosomiasis - PubMed (original) (raw)

The burden of human African trypanosomiasis

Eric M Fèvre et al. PLoS Negl Trop Dis. 2008.

Abstract

Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis. We review current knowledge on the burden of HAT in sub-Saharan Africa, with an emphasis on the disability-adjusted life year (DALY), data sources, and methodological issues relating to the use of this metric for assessing the burden of this disease. We highlight areas where data are lacking to properly quantify the impact of these diseases, mainly relating to quantifying under-reporting and disability associated with infection, and challenge the HAT research community to tackle the neglect in data gathering to enable better evidence-based assessments of burden using DALYs or other appropriate measures.

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Conflict of interest statement

There are no financial, personal, or professional interests that could be construed to have influenced this paper. PL is the Head of research at the National Control Programme against HAT in DRC.

Figures

Figure 1

Figure 1. Map of Sleeping Sickness.

Image credit: .

Figure 2

Figure 2. Child with Resolved Exfoliative Dermatitis (Epidermal Necrolysis) Resulting from Early Stage T.b. rhodesiense HAT Treatment with Suramin.

The acute stage of this condition presents with blistering and the peeling off of large areas of skin; complications due to secondary infection are likely. Image credit: Eric Fèvre.

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References

    1. Picozzi K, Carrington M, Welburn SC. A multiplex PCR that discriminates between Trypanosoma brucei brucei and zoonotic T. b. rhodesiense. Exp Parasitol. 2008;118:41–46. - PubMed
    1. Radwanska M, Claes F, Magez S, Magnus E, Perez-Morga D, et al. Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense. Am J Trop Med Hyg. 2002;67:289–295. - PubMed
    1. Picozzi K, Fèvre EM, Odiit M, Carrington M, Eisler M, et al. Sleeping sickness in Uganda: a thin line between two fatal diseases. BMJ. 2005;331:1238–1241. - PMC - PubMed
    1. Gooding RH, Krafsur ES. Tsetse genetics: applications to biology and systematics. In: Maudlin I, Holmes PH, Miles MA, editors. The trypanosomiases. Wallingford: CABI; 2004. pp. 95–111.
    1. Onyango RJ, van Hoeve K, de Raadt P. The epidemiology of Trypanosoma rhodesiense sleeping sickness in Alego location, central Nyanza, Kenya. I. Evidence that cattle may act as reservoir hosts of trypanosomes infective to man. Trans R Soc Trop Med Hyg. 1966;60:175–182. - PubMed

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