The SCID mouse mutant: definition, characterization, and potential uses - PubMed (original) (raw)
Review
The SCID mouse mutant: definition, characterization, and potential uses
M J Bosma et al. Annu Rev Immunol. 1991.
Abstract
Mice homozygous for the scid mutation (scid mice) are severely deficient in functional B and T lymphocytes. The mutation appears to impair the recombination of antigen receptor genes and thereby causes an arrest in the early development of B and T lineage-committed cells; other hematopoietic cell types appear to develop and function normally. The arrest in lymphocyte development is not absolute; some young adult scid mice are "leaky" and generate a few clones of functional B and T cells. By 10-14 months of age, virtually all scid mice are leaky. Scid mice readily support normal lymphocyte differentiation and can be reconstituted with normal lymphocytes from other mice and even partially reconstituted with human lymphocytes. They also support the growth of allogeneic and xenogeneic tumors. Thus, scid mice are of interest for studies of both normal and abnormal lymphocyte development and function. In addition, they can be used to study the function of nonlymphoid cell types in the absence of lymphocytes.
Similar articles
- The SCID mouse.
Pla M, Mahouy G. Pla M, et al. Nouv Rev Fr Hematol (1978). 1991;33(6):489-91. Nouv Rev Fr Hematol (1978). 1991. PMID: 1818304 Review. - T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.
Petrini JH, Carroll AM, Bosma MJ. Petrini JH, et al. Proc Natl Acad Sci U S A. 1990 May;87(9):3450-3. doi: 10.1073/pnas.87.9.3450. Proc Natl Acad Sci U S A. 1990. PMID: 2159151 Free PMC article. - T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway.
Shores EW, Sharrow SO, Uppenkamp I, Singer A. Shores EW, et al. Eur J Immunol. 1990 Jan;20(1):69-77. doi: 10.1002/eji.1830200111. Eur J Immunol. 1990. PMID: 1968394 - B and T cell leakiness in the scid mouse mutant.
Bosma MJ. Bosma MJ. Immunodefic Rev. 1992;3(4):261-76. Immunodefic Rev. 1992. PMID: 1449786 Review.
Cited by
- Combining CD38 antibody with CD47 blockade is a promising strategy for treating hematologic malignancies expressing CD38.
Li S, Chen D, Yang Y, Guo H, Liu D, Sun N, Bai X, Wang K, Li T, Li G, Yang C, Zhang W, Zhang L, Zhao G, Peng L, Liu S, Tu X, Zhang R, Tian W. Li S, et al. Front Immunol. 2024 Jun 25;15:1398508. doi: 10.3389/fimmu.2024.1398508. eCollection 2024. Front Immunol. 2024. PMID: 38983860 Free PMC article. - SCID mice in the study of human autoimmune diseases.
Duchosal MA. Duchosal MA. Springer Semin Immunopathol. 1992;14(2):159-77. doi: 10.1007/BF00195292. Springer Semin Immunopathol. 1992. PMID: 1475742 Review. No abstract available. - Scrapie pathogenesis in subclinically infected B-cell-deficient mice.
Frigg R, Klein MA, Hegyi I, Zinkernagel RM, Aguzzi A. Frigg R, et al. J Virol. 1999 Nov;73(11):9584-8. doi: 10.1128/JVI.73.11.9584-9588.1999. J Virol. 1999. PMID: 10516067 Free PMC article. - A Three-Dimensional Organoid Model of Primary Breast Cancer to Investigate the Effects of Oncolytic Virotherapy.
Carter ME, Hartkopf AD, Wagner A, Volmer LL, Brucker SY, Berchtold S, Lauer UM, Koch A. Carter ME, et al. Front Mol Biosci. 2022 Feb 11;9:826302. doi: 10.3389/fmolb.2022.826302. eCollection 2022. Front Mol Biosci. 2022. PMID: 35223990 Free PMC article. - Characterization of the CD154-positive and CD40-positive cellular subsets required for pathogenesis in retrovirus-induced murine immunodeficiency.
Green KA, Noelle RJ, Durell BG, Green WR. Green KA, et al. J Virol. 2001 Apr;75(8):3581-9. doi: 10.1128/JVI.75.8.3581-3589.2001. J Virol. 2001. PMID: 11264347 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources