Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies - PubMed (original) (raw)
Meta-Analysis
Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies
Michael Huncharek et al. Nutr Cancer. 2009.
Abstract
In vivo and in vitro studies suggest that dairy products, calcium, and dietary vitamin D inhibits the development of colorectal cancer (CRC). A meta-analysis was performed to evaluate this relationship in observational studies. Data from 60 epidemiological studies enrolling 26,335 CRC cases were pooled using a general variance-based meta-analytic method. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated for the highest vs. the lowest intake categories. Sensitivity analyses tested the robustness of these summary effect measures and the statistical heterogeneity. The summary RR for high milk and dairy product intake, respectively, on colon cancer risk was 0.78 (95% CI = 0.67-0.92) and 0.84 (95% CI = 0.75-0.95). Milk intake was unrelated to rectal cancer risk. High calcium intake had a greater protective effect against tumors of the distal colon and rectal cancer vs. proximal colon. The risk reduction associated with calcium was similar for dietary and supplemental sources. Vitamin D was associated with a nonsignificant 6% reduction in CRC risk. Higher consumption of milk/dairy products reduces the risk of colon cancer, and high calcium intake reduces the risk of CRC. Low vitamin D intake in the study populations may limit the ability to detect a protective effect if one exists.
Similar articles
- Dairy products, dietary calcium and vitamin D intake as risk factors for prostate cancer: a meta-analysis of 26,769 cases from 45 observational studies.
Huncharek M, Muscat J, Kupelnick B. Huncharek M, et al. Nutr Cancer. 2008;60(4):421-41. doi: 10.1080/01635580801911779. Nutr Cancer. 2008. PMID: 18584476 - Prospective study on milk products, calcium and cancers of the colon and rectum.
Järvinen R, Knekt P, Hakulinen T, Aromaa A. Järvinen R, et al. Eur J Clin Nutr. 2001 Nov;55(11):1000-7. doi: 10.1038/sj.ejcn.1601260. Eur J Clin Nutr. 2001. PMID: 11641750 - Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis.
Gao X, LaValley MP, Tucker KL. Gao X, et al. J Natl Cancer Inst. 2005 Dec 7;97(23):1768-77. doi: 10.1093/jnci/dji402. J Natl Cancer Inst. 2005. PMID: 16333032 - Intake of dairy products and risk of colorectal neoplasia.
Pufulete M. Pufulete M. Nutr Res Rev. 2008 Jun;21(1):56-67. doi: 10.1017/S0954422408035920. Nutr Res Rev. 2008. PMID: 19079854 Review. - Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence.
Norat T, Riboli E. Norat T, et al. Eur J Clin Nutr. 2003 Jan;57(1):1-17. doi: 10.1038/sj.ejcn.1601522. Eur J Clin Nutr. 2003. PMID: 12548291 Review.
Cited by
- Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients.
Wesselink E, Gauderman W, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Chan AT, Chang-Claude J, Cotterchoi M, Gunter MJ, Hoffmeister M, Joshi AD, Newton CC, Pai RK, Pellatt AJ, Phipps AI, Song M, Um CY, van Guelpen B, White E, Peters U, van Duijnhoven FJB. Wesselink E, et al. BJC Rep. 2024;2(1):63. doi: 10.1038/s44276-024-00077-3. Epub 2024 Sep 2. BJC Rep. 2024. PMID: 39233917 Free PMC article. - Risk factors of colorectal cancer: the comparison of selected nutritional behaviors of medical and non-medical students.
Malinowska D, Milewski R, Żendzian-Piotrowska M. Malinowska D, et al. J Health Popul Nutr. 2023 May 30;42(1):50. doi: 10.1186/s41043-023-00389-z. J Health Popul Nutr. 2023. PMID: 37254180 Free PMC article. - Dietary patterns and risk of colorectal cancer: a comparative analysis.
Wang P, Song M, Eliassen AH, Wang M, Giovannucci EL. Wang P, et al. Int J Epidemiol. 2023 Feb 8;52(1):96-106. doi: 10.1093/ije/dyac230. Int J Epidemiol. 2023. PMID: 36515537 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical