Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain - PubMed (original) (raw)
doi: 10.1038/nsmb.1543. Epub 2009 Jan 4.
Affiliations
- PMID: 19122660
- DOI: 10.1038/nsmb.1543
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
Esben M Quistgaard et al. Nat Struct Mol Biol. 2009 Jan.
Abstract
The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller.
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