Evidence that matrix recognition contributes to stabilization but not induction of LTP - PubMed (original) (raw)
Comparative Study
Evidence that matrix recognition contributes to stabilization but not induction of LTP
P Xiao et al. Neuroreport. 1991 Aug.
Erratum in
- Neuroreport 1991 Sep;2(9):following 546
Abstract
Slices of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, they did produce a reversible, dose dependent decay of LTP over a period of 40 min. This effect was not obtained with various non-RGD control peptides. These results suggest that stabilization of LTP requires adhesive interactions via specific matrix recognition sites, whereas induction and expression do not.
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