N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1) - PubMed (original) (raw)
. 2009 Feb 15;19(4):1218-23.
doi: 10.1016/j.bmcl.2008.12.075. Epub 2008 Dec 24.
Sukhdev Manku, Eric Therrien, Natalie Nguyen, Sylvia Styhler, Marie-France Robert, Anne-Christine Goulet, Andrea J Petschner, Gabi Rahil, A Robert Macleod, Robert Déziel, Jeffrey M Besterman, Hannah Nguyen, Amal Wahhab
Affiliations
- PMID: 19131248
- DOI: 10.1016/j.bmcl.2008.12.075
N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)
Martin Allan et al. Bioorg Med Chem Lett. 2009.
Abstract
A series of N-benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides targeting co-activator associated arginine methyltransferase 1 (CARM1) have been designed and synthesized. The potency of these inhibitors was influenced by the nature of the heteroaryl fragment with the thiophene analogues being superior to thiazole, pyridine, isoindoline and benzofuran based inhibitors.
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